Relationship Between Flt3L,TGF-β1 and EGFR and Poor Prognosis in Patients with Acute Myelogenous Leukemia
Objective To explore whether ROCK2 affects invasion and metastasis of liver cancer cells by regulating MKP1 expression.Methods 120 patients with firstly-diagnosed AML were selected as the observation group,and 100 healthy volunteers who underwent physical examination during the same period were recruited as the control group.The levels of Flt3L,TGF-β1 and EGFR were compared between the 2 groups.The patients in the observation group were followed up for 3 to 12 months after discharge,and were divided into good group(86 cases)and poor group(34 cases)according to the prognosis sta-tus.The clinical data of the 2 groups were compared,and COX model was used to analyze the relationship between the above indi-cators and poor prognosis,and receiver operating characteristic(ROC)curve was adopted to explore the predictive efficiency of the above indicators on poor prognosis in patients with AML.Results The levels of Flt3L and TGF-β1 in the observation group were lower than those in the control group while the level of EGFR was higher than that in the control group(P＜0.05).There were statistical differences in the levels of Flt3L,TGF-β1 and EGFR among patients with different prognosis status(P＜0.05).COX model analysis showed that the levels of Flt3L,TGF-β1 and EGFR were independent influencing factors for poor prognosis in AML patients(P＜0.05).ROC curve analysis revealed that the AUCs of levels of Flt3L,TGF-β1 and EGFR in predicting the poor prognosis in patients with AML were 0.874,0.838 and 0.858 respectively.Conclusion Flt3L,TGF-β1 and EGFR are as-sociated with poor prognosis in patients with AML.
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