Effect of Sequential Downgrade Ventilation on Lung Cancer Patients with Respiratory Failure
Objective To explore the effect of sequential downgrade of ventilation on lung cancer patients with respirato-ry failure.Methods 80 lung cancer patients complicating respiratory failure were selected,and divided into 2 groups according to random number table methods,each with 40 cases.When pulmonary infection control window(PIC-Window)occurred,the control group received invasive mechanical ventilation,while the observation group received sequential invasive-noninvasive mechanical ventilation.Then comparison was conducted on the vital signs,blood gas analysis index,mechanical ventilation time,ICU stay time,the incidence of ventilator-associated pneumonia(VAP),success rate of weaning from mechanical ventilation and the treat-ment outcomes.Results After treatment,a decrease in heart rate and respiratory rate,and an increase in PaO2 were detected in both groups(P＜0.05),while the 3 indicators yielded no statistical difference between groups(P＞0.05).The pre-and post-treatment blood pressure,pH value and PaCO2 demonstrated no statistical difference between the 2 groups(P＞0.05).Compared with the control group,the observation group had decreased time to mechanical ventilation and ICU stay length,lower VAP rate,and higher success rate of weaning from mechanical ventilation,with statistical difference(P＜0.05).Among 40 patients in the observation group,31 patients were successfully weaned from mechanical ventilation,5 patients switched to invasive ventilation a-gain,and the remaining4 patients still applied non-invasive positive pressure ventilation and transferred to the general ward.In the control group,22 patients were successfully weaned from mechanical ventilation,18 patients still applied non-invasive ventilation,and 1 died in ICU due to the infection.Conclusion Application of sequential invasive-noninvasive mechanical ventilation in the treatment of respiratory failure in lung cancer patients can effectively ameliorate the hemodynamic indexes and oxygenation capaci-ty,shorten the mechanical ventilation time and ICU stay length,reduce the VAP rate,and improve the success rate of weaning from mechanical ventilation,which is of great clinical value.
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