Application Effect of Different Doses of Iodine-131 in Patients With Non-distant Metastatic High-risk Differentiated Thyroid Carcinoma After Total Thyroidectomy
Objective To explore the application effect of different doses of iodine-131 in patients with non-distant me-tastatic high-risk differentiated thyroid carcinoma(DTC)after total thyroidectomy.Methods A retrospective analysis was per-formed on the clinical data of 86 patients with non-distant metastatic high-risk DTC.All patients underwent total thyroidectomy.According to different doses of iodine-131,they were divided into low-dose group(100～150 mcI,45 cases)and high-dose group(150～200 mci,41 cases).All were treated for 3 months and followed up for 1 year.The clinical treatment related indexes(suc-cess rate of thyroidectomy,disease-free survival rate,hospitalization time),score of thyroid cancer-specific quality of life(THY-CA-QoL)and the occurrence of adverse reactions were compared between the 2 groups.Results After treatment and follow-up,there was no significant difference in the success rate of thyroidectomy between the 2 groups(P＞0.05).The disease-free surviv-al rate in low-dose group was higher than that in high-dose group(95.56％vs 80.49％),and hospitalization time was shorter than that in high-dose group(P＜0.05).After treatment,scores of THYCA-QoL(physiological function and activity,psychologi-cal function,symptoms or impact on life)in both groups were increased,which were higher in low-dose group than high-dose group(P＜0.05).The incidence of adverse reactions in low-dose group was lower than that in high-dose group(8.89％vs 29.27％,P＜0.05).Conclusion Low-dose and high-dose iodine-131 have the same curative effect on patients with non-distant metastatic high-risk DTC after total thyroidectomy.However,the former is more beneficial to shorten hospitalization time,improve disease-free survival rate,reduce the occurrence of adverse reactions and improve quality of life.
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