两种不同剂量碘-131对非远处转移性高危分化型甲状腺癌全切术后患者DTC的应用效果
Application Effect of Different Doses of Iodine-131 in Patients With Non-distant Metastatic High-risk Differentiated Thyroid Carcinoma After Total Thyroidectomy
闫志华 1程兵 1李祥周 1陈伟娜1
作者信息
摘要
目的 探讨两种不同剂量碘-131对非远处转移性高危分化型甲状腺癌(DTC)全切术后患者的应用效果.方法 回顾性分析86例非远处转移性高危DTC患者的临床资料,所有患者均行DTC全切术,并按照碘-131治疗剂量的不同分成低剂量组(100～150 mCi)和高剂量组(150～200 mCi),前者为45例,后者为41例,治疗3个月,随访1年.比较两组相关临床治疗指标(清甲成功率、无病生存率、住院隔离时间)、甲状腺癌特异性生命质量量表(THYCA-QoL)和不良反应发生情况的差异.结果 治疗及随访结束后,两组的清甲成功率无明显差异(P＜0.05),低剂量组的无病生存率(95.56％)高于高剂量组(80.49％),且住院隔离时间短于高剂量组(P＜0.05);两组生理功能和活动、心理功能、症状或对生活影响评分均高于同组治疗前,且低剂量组THYCA-QoL评分均高于高剂量组(P＜0.05);低剂量组不良反应发生率(8.89％)低于高剂量组(29.27％)(P＜0.05).结论 低剂量和高剂量碘-131对于非远处转移性高危DTC全切术后患者的治疗效果相当,但前者更有利于缩短住院隔离时间,提高无病生存率,减少不良反应的发生,进而提高生存质量.
Abstract
Objective To explore the application effect of different doses of iodine-131 in patients with non-distant me-tastatic high-risk differentiated thyroid carcinoma(DTC)after total thyroidectomy.Methods A retrospective analysis was per-formed on the clinical data of 86 patients with non-distant metastatic high-risk DTC.All patients underwent total thyroidectomy.According to different doses of iodine-131,they were divided into low-dose group(100～150 mcI,45 cases)and high-dose group(150～200 mci,41 cases).All were treated for 3 months and followed up for 1 year.The clinical treatment related indexes(suc-cess rate of thyroidectomy,disease-free survival rate,hospitalization time),score of thyroid cancer-specific quality of life(THY-CA-QoL)and the occurrence of adverse reactions were compared between the 2 groups.Results After treatment and follow-up,there was no significant difference in the success rate of thyroidectomy between the 2 groups(P＞0.05).The disease-free surviv-al rate in low-dose group was higher than that in high-dose group(95.56％vs 80.49％),and hospitalization time was shorter than that in high-dose group(P＜0.05).After treatment,scores of THYCA-QoL(physiological function and activity,psychologi-cal function,symptoms or impact on life)in both groups were increased,which were higher in low-dose group than high-dose group(P＜0.05).The incidence of adverse reactions in low-dose group was lower than that in high-dose group(8.89％vs 29.27％,P＜0.05).Conclusion Low-dose and high-dose iodine-131 have the same curative effect on patients with non-distant metastatic high-risk DTC after total thyroidectomy.However,the former is more beneficial to shorten hospitalization time,improve disease-free survival rate,reduce the occurrence of adverse reactions and improve quality of life.
关键词
碘-131/不同剂量/非远处转移性/分化型甲状腺癌/甲状腺全切术Key words
Iodine-131/Different dose/Non-distant metastasis/Differentiated thyroid carcinoma/Total thyroidectomy引用本文复制引用
出版年
2024
NETL
NSTL
万方数据