曲妥珠单抗联合SOX方案治疗进展期胃癌的效果及对患者血清肿瘤标志物水平的影响
Curative Effect of Trastuzumab Combined with SOX Regimen on Patients With Advanced Gastric Cancer and Its Influences on Serum Tumor Markers
户军燕 1邱作栋 1周宁 1于婷1
作者信息
摘要
目的 探究曲妥珠单抗联合替吉奥+奥沙利铂(SOX)方案治疗进展期胃癌(AGC)的效果及对患者血清肿瘤标志物水平的影响.方法 选取68例AGC患者作为研究对象,并按随机数字表法分成对照组(34例)和研究组(34例).对照组给予SOX方案治疗,研究组给予曲妥珠单抗联合SOX方案治疗.比较2组疗效、血清肿瘤标志物[糖类抗原724(CA724)、癌胚抗原(CEA)、糖类抗原199(CA199)]水平、免疫功能(IgA、IgG、IgM)水平和药物毒副作用发生率的差异.结果 治疗后,研究组总有效率为67.65％,高于对照组的41.18％(P＜0.05).治疗后,2组的血清CA724、CEA、CA199水平均低于同组治疗前,且研究组低于对照组(P＜0.05);2组的IgA、IgG、IgM水平低于同组治疗前,但研究组的水平高于对照组(P＜0.05).2组药物毒副作用的发生率无明显差异(P＞0.05).结论 曲妥珠单抗联合SOX方案对AGC的治疗效果显著,能有效降低患者血清肿瘤标志物水平,减弱化疗对机体的免疫抑制功能,且应用较安全.
Abstract
Objective To explore the curative effect of trastuzumab combined with oxaliplatin+S-1(SOX)regimen on patients with advanced gastric cancer(AGC)and its influences on levels of serum tumor markers.Methods A total of 68 pa-tients with AGC were enrolled as the research objects.According to random number table method,they were divided into the con-trol group(34 cases)and the study group(34 cases).The control group was treated with SOX regimen,while the study group was additionally treated with trastuzumab.The curative effect,serum tumor markers[carbohydrate antigen 724(CA724),carcino-embryonic antigen(CEA),carbohydrate antigen 199(CA199)],immunoglobulins(IgA,IgG,IgM)and incidence of drugs toxic-ity were compared between the 2 groups.Results After treatment,total response rate of the study group was higher than that of the control group(67.65％vs 41.18％,P＜0.05).After treatment,levels of serum CA724,CEA and CA199 in both groups were decreased,which were lower in the study group than the control group(P＜0.05).After treatment,levels of IgA,IgG and IgM in both groups were decreased,which were higher in the study group than the control group(P＜0.05).There was no significant difference in the incidence of drugs toxicity between the 2 groups(P＞0.05).Conclusion Trastuzumab combined with SOX regimen has significant curative effect on AGC patients,which can effectively reduce levels of serum tumor markers and weaken immunosuppressive function,with high application safety.
关键词
曲妥珠单抗/SOX方案/进展期胃癌/效果/肿瘤标志物Key words
Trastuzumab/SOX regimen/Advanced gastric cancer/Effect/Tumor marker引用本文复制引用
出版年
2024
NETL
NSTL
万方数据