Impact of Tumor Volume on Prognosis of Patients with Advanced Rectal Cancer after Intensity Modulated Radiotherapy
Objective To discuss the impact of tumor volume on prognosis of patients with advanced rectal cancer after intensity modulated radiotherapy.Methods 96 patients with advanced rectal cancer were retrospectively analyzed.All patients received intensity modulated radiotherapy.Analysis was performed on clinical data.Receiver Operating Characteristic(ROC)curve was used to calculate the tumor volume cutoff value,and the Kaplan-Meier and Cox proportional hazards survival regression analysis were conducted to analyze the prognosis of patients.Results In the evaluation of prognostic death of advanced rectal cancer,ROC curve found that the cutoff value,sensitivity,specificity,and AUC value of tumor volume were 81.68 mL,75.0％,87.5％and 0.804.Patients with different tumor volume yielded statistical difference in TNM stage,differentiation degree and lymph node metastasis status(P＜0.05).Pearson correlation analysis denoted that the tumor volume was positively correlated with TNM stage and lymph node metastasis(P＜0.05),and negatively correlated with differentiation degree(P＜0.05).13 out of 96 patients died and 2 had local recurrence.The survival rates of tumor volume＞81.68 mL(n=32)and tumor volume ≤81.68 mL(n=64)were 68.75％and 96.87％,respectively(P＜0.05).Conclusion Tumor volume is closely related to the prognosis and death of patients with advanced rectal cancer receiving IMRT,and its volume is significantly correlated with TNM stage,dif-ferentiation degree and lymph node metastasis.
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