摘要
目的 探讨腹腔镜下根治性膀胱切除术患者伴偶发前列腺癌的相关因素.方法 回顾性分析65例腹腔镜下根治性膀胱切除术患者的临床资料,统计其偶发前列腺癌发生情况.结果 65例腹腔镜下行根治性膀胱切除术患者中,偶发前列腺癌共12例,发生率为18.46％(12/65);单因素分析显示:高血压史、糖尿病史、肿瘤直径与腹腔镜下根治性膀胱切除术患者偶发前列腺癌发生无关(P＞0.05);而年龄、BMI、吸烟史、饮酒史、前列腺体积与偶发前列腺癌发生有关(P＜0.05);多因素 Logistic 回归分析显示:年龄 ≥60 岁(β=1.531,OR=4.625,95％CI=1.216～17.590)、BMI≥28 kg/m2(β=1.599,OR=4.950,95％CI=1.197～20.474)、有吸烟史(β=1.795,OR=6.020,95％CI=1.579～22.947)、有饮酒史(β=1.764,OR=5.833,95％CI=1.403～24.253)、前列腺体积＞4 cm × 3 cm × 2 cm(β=1.623,OR=5.067,95％CI=1.326～19.365)为腹腔镜下根治性膀胱切除术患者偶发前列腺癌发生的主要危险因素(P＜0.05).结论 腹腔镜下根治性膀胱切除术患者偶发前列腺癌发生风险较高,而其发生的因素具有多样性,如年龄≥60岁、BMI≥28 kg/m2、有吸烟史、有饮酒史等.
Abstract
Objective To explore the related factors of incidental prostate cancer in patients undergoing laparoscopic radical cystectomy.Methods A retrospective analysis was conducted on the clinical data of 65 patients undergoing laparoscopic radical cystectomy,and the incidence of incidental prostate cancer was analyzed.Results Among the 65 patients undergoing lap-aroscopic radical cystectomy,12 cases had occasional prostate cancer,with an incidence rate of 18.46％(12/65);Univariate a-nalysis showed that the history of hypertension,diabetes,and tumor diameter were not related to the incidences of prostate cancer in patients undergoing laparoscopic radical cystectomy(P＞0.05);Age,BMI,smoking history,alcohol consumption history,and prostate volume are associated with the occurrence of incidental prostate cancer(P＜0.05);Multivariate logistic regression analy-sis showed that age ≥ 60 years old(β=1.531,OR=4.625,95％CI=1.216～17.590),BMI ≥28 kg/m2(β=1.599,OR=4.950,95％CI=1.197～20.474),with a history of smoking(β=1.795,OR=6.020,95％CI=1.579～22.947),with a histo-ry of drinking alcohol(β=1.764,OR=5.833,95％CI=1.403～24.253),prostate volume＞4 cm × 3 cm x 2 cm(β=1.623,OR=5.067,95％CI=1.326～19.365)was the main risk factor for incidental prostate cancer in patients undergoing laparo-scopic radical cystectomy(P＜0.05).Conclusion Laparoscopic radical cystectomy patients have a higher risk of incidental prostate cancer,and the factors for its occurrence are diverse,such as age ≥ 60 years old,BMI≥28 kg/m2,smoking history,and drinking history.
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