Effect of Liver Volume Changes on Liver Function and Prognosis in Patients with Liver Metastases After TACE
Objective To investigate the influence of liver volume changes on liver function and prognosis in patients with liver metastases after transcatheter arterial chemoembolization(TACE).Methods The clinical data of 86 patients with liver metastases were analyzed retrospectively.All patients were treated with TACE,and the residual liver volume(LV)and tumor vol-ume(TV)were evaluated by CT before and after the operation;The patients were divided into 2 groups according to the situation of liver function injury after TACE.The general data of the 2 groups were collected,and the independent risk factors of liver function injury after TACE were obtained through Logistic regression analysis;Draw ROC curve to analyze the clinical value of LV in pre-dicting liver function injury;The relationship between liver volume change and prognosis was analyzed.Results Among 86 pa-tients with liver metastasis,19 patients had liver function injury after TACE,the injury rate was 22.09％(19/86);The LV in the liver injury group was lower than that in the non injury group,and the TV was higher than that in the non injury group(P＜0.05);The ROC curve showed that the area under the curve of LV and TV predicting liver function damage after TACE was 0.916 and 0.603,respectively.LV had a higher predictive value;Multivariate analysis showed that △LV grade and preoperative Child Pugh grade were independent influencing factors for liver function damage in patients with liver metastases after TACE(P＜0.05 and OR＞1);The median survival time of all patients was 15 months,the median survival time of △LV1 patients was 17 months,and the median survival time of △LV2 patients was 12 months;At the end of follow-up,the survival rate of △LV1 pa-tients was 78.95％(45/57),and that of △ LV2 patients was 51.72％(15/29);The survival rate of patients with △LV1 was higher than that of patients with △LV2,and the difference was statistically significant(x2=6.754,P=0.009).Conclusion The liver volume of patients with liver metastases after TACE can change to some extent.The detection of LV by CT can better predict the liver function damage and help to evaluate the prognosis of patients,which is worthy of clinical attention.
Liver metastasisHepatic artery infusion chemoembolizationLiver volumeLiver function
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