The Clinical Value of MPV/PLT Ratio in Predicting Micro vascular Infiltration in Patients with Small Hepatocellular Carcinoma
Objective To investigate the clinical value of mean platelet volume(MPV)to platelet count(PLT)ratio(MPV/PLT)in predicting microvascular infiltration(MVI)in patients with small liver cancer.Methods The clinical data of 153 patients with small liver cancer were retrospectively analyzed.According to whether patients complicated with MVI after oper-ation,they were divided into MVI group(70 cases)and non MVI group(83 cases).MPV and PLT were detected in all patients with liver cancer after admission,and MPV/PLT was calculated.The differences of MPV/PLT between MVI group and non MVI group were compared.The predictive value of MPV/PLT for MVI in patients with liver cancer was analyzed by receiver operating characteristic curve(ROC).The related factors for MVI in patients with liver cancer were analyzed by multivariate logistic regres-sion.Results Compared with the non-MVI group,the MPV level in the MVI group was higher,and PLT level was lower(P＜0.05).The level of MPV/PLT in MVI group was significantly higher than that in non MVI group(P＜0.05).The ROC curve showed that the area,cut-off value,sensitivity and specificity under MPV/PLT curve were 0.825,0.060,82.5％and 89.6％,re-spectively,which were higher than those of MPV and PLT(P＜0.05).Univariate analysis showed that there were significant differences in AFP level,tumor diameter,degree of differentiation and MPV/PLT level between MVI group and non MVI group(P＜0.05).Multivariate logistic regression analysis showed that the low differentiation,tumor diameter＞3 cm,AFP＞200 ng/ml and MPV/PLT＞0.060 were the risk factors of MVI in patients with liver cancer(P＜0.05).Conclusion The level of MPV/PLT is significantly increased in patients with small liver cancer complicated with microvascular infiltration,which is a related fac-tor affecting the complications of MVI in patients with small liver cancer,and is expected to be an effective biomarker for predic-ting the complications of MVI in patients with small liver cancer.
Ratio of average platelet volume to platelet countLiver cancerMicrovascular infiltrationPredictive value
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