Expressions and Clinical Significance of PI3K and NF-κB p65 Proteins in Cervical Cancer Tissues
Objective To explore the expressions and clinical significance of phosphatidylinositol-3-kinase(PI3K)and nuclear transcription factor κB(NF-κB)p65 proteins in cervical cancer tissues.Methods A total of 62 patients with cervical cancer were enrolled as the research objects.The cervical cancer and para-carcinoma tissues were collected to detect expressions of PI3K and NF-κB p65 proteins by immunohistochemical staining.The positive REG4 and Sp1 proteins in cervical cancer and para-carcinoma tissues were compared.The correlation between PI3K,NF-κB p65 proteins and clinicopathological parameters was analyzed.Results The differences in positive expression rates of PI3K and NF-κB p65 proteins between cervical cancer tissues and para-carcinoma tissues were statistically significant(62.90％,69.35％vs 0％,0％,P<0.05).There was no significant difference in positive expressions of PI3K and NF-κB p65 proteins among patients with different age,pathological classifications and tumor diameter(P>0.05).The positive expression rates of PI3K and NF-κB p65 in patients with FIGO staging at stages Ⅲ～Ⅳ were 76.92％and 82.05％,higher than those at stages Ⅰ～Ⅱ(39.13％,47.83％,P<0.05).The positive expression rates of PI3K and NF-κB p65 were the highest in patients with low differentiation(83.33％,94.44％),followed by medium dif-ferentiation(61.11％,63.89％)and high differentiation(25.00％,37.5％;P<0.05).The positive expression rates of PI3K and NF-κB p65 in patients with lymph node metastasis were86.96％and 95.65％,higher than those without metastasis(48.72％,53.85％;P<0.05).Correlation analysis showed that expression levels of PI3K and NF-κB p65 proteins were positively correla-ted with FIGO staging and lymph node metastasis,while negatively correlated with differentiation degree(P<0.05).Conclusion The positive expression rates of PI3K and NF-κB p65 proteins in cervical cancer tissues are higher than those in normal para-car-cinoma tissues,which are positively correlated with FIGO staging and lymph node metastasis,while negatively correlated with dif-ferentiation degree.The two indexes have certain clinical significance for the diagnosis and treatment of cervical cancer.
万方数据
维普
