FGFR1 Protein Expression in ER-positive Breast Cancer and Its Correlation with ER and Prognosis
Objective To explore the expression level of fibroblast growth factor receptor 1(FGFR1)protein in oestro-gen receptor(ER)-positive breast cancer and its relationship with ER and prognosis.Methods Clinical data of 89 ER-positive breast cancer patients were also retrospectively analyzed.All patients underwent surgical treatment,and the tumor samples were tested for FGFR1 protein expression by immunohistochemistry,the expression level of FGFR1 protein expression in ER-positive breast cancer was counted,and the clinicopathological characteristics of patients with different FGFR1 expression were analyzed,and the survival rate of patients with different FGFR1 protein expression were compared.Results FGFR1 protein expression was present in all 89 patients with ER-positive breast cancer,Among these,in 58 cases with high expression,Low expression in 31 ca-ses;Compared with tumor stage,tumor size,lymph node metastasis,and ER expression,The difference was statistically significant(P<0.05);Follow-up for 3 years,89 ER-positive patients survived 71,The survival rate was 79.78 5%(71/89);The survival rate of the FGFR1 protein low expression group was 93.55%(29/31),Higher than 72.41%(42/58)of high FGFR1 protein ex-pression group,The difference was statistical significant(x2 =5.593,P = 0.018).Conclusion FGFR1 protein is widely ex-pressed in ER-positive breast cancer,and ER expression has low levels in patients with high FGFR1 protein expression,and can affect the prognosis of patients,which can strengthen the treatment of patients with high FGFR1 protein expression to improve the long-term survival rate.
Breast cancerEstrogen receptorPathologic featuresClinical prognosis
万方数据
维普
