Correlation Analysis Between Changes in Serum Tumor Markers Expression and Clinical Pathological Characteristics in Lung Cancer Patients
Objective To explore the relationship between the levels of tumor markers and the clinical pathological char-acteristics of lung cancer patients,and to provide reference for further improving clinical treatment in clinical practice.Methods 60 lung cancer patients were selected as the observation group,and another 60 healthy individuals in the same period were select-ed as the control group.All patients underwent blood sampling for detection of carcinoembryonic antigen(CEA),carbohydrate an-tigen 153(CA153),and cytokeratin 19 fragment(CYFPA21-1).The differences in CEA,CA153,and CYFPA21-1 levels between the 2 groups were compared,and the differences in CEA,CA153,and CYFPA21-1 levels between patients with different pathologi-cal types,TNM staging,differentiation,and lymph node metastasis were analyzed.Results The levels of CEA,CA153,and CYF-PA21-1 in the observation group were(34.58±4.35)ng/mL,(53.84±5.37)U/mL,and(10.69±1.42)ng/mL,which were higher than those in the control group(1.45±0.26)ng/mL,(10.21±1.58)U/mL,and(1.36±0.22)ng/mL,with a statisti-cally significant difference(P<0.05).The levels of CEA,CA153,and CYFPA21-1 in patients with TNM stage Ⅲ～Ⅳ,low to medium differentiation,and lymph node metastasis were higher than those in patients with stage Ⅰ～Ⅱ,high differentiation,and no lymph node metastasis,with statistical significance(P<0.05).Conclusion CEA,CA153,and CYFPA21-1 are highly ex-pressed in lung cancer,and their expression is closely related to TNM staging,differentiation,and lymph node metastasis.Clinical evaluation of lung cancer condition can be achieved by detecting these indicators to carry out targeted treatment and improve pa-tient prognosis.
万方数据
维普
