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食管癌根治术患者术后肺部感染的相关危险因素分析

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目的 探讨食管癌患者根治术后肺部感染的相关危险因素.方法 回顾性分析120 例食管癌患者临床资料.所有患者均接受食管癌根治术治疗,依据术后是否发生肺部感染分为感染组与未感染组,收集2 组年龄、性别、体质量指数等基线资料,经Logistic回归分析,获取影响食管癌患者术后肺部感染发生的独立危险因素.结果 120 例患者共26 例术后发生肺部感染,发生率为21.67%(26/120).单因素分析显示,年龄、手术时间、术中出血量、术前白蛋白水平、手术通气方式、糖尿病、慢阻肺、吸烟史、术前肺功能与术后肺部感染发生有关(P<0.05),多因素分析显示,年龄≥65 岁、手术时间≥4 h、术中出血量≥200 mL、术前白蛋白水平<30 g/L、单肺通气、糖尿病、慢阻肺、吸烟史、术前肺功能(FEV1/FVC)<70%为术后肺部感染发生的独立危险因素(P<0.05 且OR>1).结论 食管癌患者根治术后肺部感染发生风险较高,且与年龄、手术时间、术中出血量、术前白蛋白水平等密切相关,临床需尽早开展针对性干预,减少肺部感染的发生.
Analysis of Related Risk Factors of Postoperative Pulmonary Infection in Patients Under-went Radical Esophageal Cancer
Objective To investigate the relevant risk factors of pulmonary infection after radical surgery in patients with esophageal cancer.Methods The clinical data of 120 patients with oesophageal cancer were also retrospectively analyzed.All pa-tients were treated with radical esophageal cancer,and were divided into infection and non-infection groups according to whether lung infection occurred after surgery.Baseline data of age,sex,body quality index and other data of the 2 groups were collected.Independent risk factors affecting the occurrence of postoperative lung infection in esophageal cancer patients were obtained by lo-gistic regression analysis.Results A total of 26 postoperative pulmonary infections occurred in 120 patients,The incidence rate was 21.67%(26/120);The univariate analysis revealed that,age,operative time,intraoperative bleeding volume,preoperative al-bumin level,mode of surgical ventilation,diabetes mellitus,COPD,smoking history,and preoperative pulmonary function were as-sociated with the occurrence of postoperative pulmonary infection,The difference was statistically significant(P<0.05);Multiva-riate analysis revealed that age≥65 years,operative time≥4 h,intraoperative bleeding volume≥200 mL,preoperative albumin level<30 g/L,single lung ventilation,diabetes,COPD,smoking history,and preoperative pulmonary function(FEV1/FVC)<70%were independent risk factors affecting the occurrence of postoperative pulmonary infection(P<0.05 and OR>1).Conclu-sion The risk of lung infection in esophageal cancer patients after radical surgery is high,which is closely related to age,opera-tion time,intraoperative bleeding volume,and preoperative albumin level.Targeted clinical intervention should be carried out as early as possible to reduce the occurrence of lung infection.

Pulmonary infectionRadical resection of esophageal cancerInfluencing factors

王乃馨、单单单、张继露、王贝

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450000 河南省人民医院

肺部感染 食管癌根治术 影响因素

2024

实用癌症杂志
江西省肿瘤医院 江西省肿瘤研究所

实用癌症杂志

影响因子:1.241
ISSN:1001-5930
年,卷(期):2024.39(2)
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