Effects of Total Thoracoscopic Lobectomy on miR-25,miR-29A,miR-126 and T Lymphocyte Subsets in Patients with Early Non-small Cell Lung Cancer
Objective To investigate the effect of total Thoracoscopy lobectomy(VATS)for early non-small cell lung cancer(NSCLC).Methods 80 NSCLC patients were divided into 2 groups using a random number table method,with 40 pa-tients in each group.The control group underwent thoracotomy,while the observation group underwent VATS.Compare the periop-erative indicators,miR related indicators,and immune function indicators between the 2 groups,and follow up for 1 year to calcu-late the total survival and progression free survival of the 2 groups.Results The hospitalization time of the observation group was shorter than that of the control group,and the postoperative drainage volume and intraoperative bleeding volume were lower than those of the control group,with statistical differences(P<0.05);There was no statistically significant difference in surgical time and number of lymph node dissection between the 2 groups(P>0.05);The levels of miR-25,miR-29A,and miR-126 in the 2 groups increased after surgery compared to before,and the observation group was higher than the control group,with a statistical difference(P<0.05);The postoperative levels of CD3+,CD4+,and CD4+/CD8+ in both groups decreased compared to before surgery,but the observation group was higher than the control group.The CD8+levels in both groups increased compared to before surgery,but the observation group was lower than the control group,with a statistical difference(P<0.05);After 1-year follow-up,there was no statistically significant difference in the progression free survival and overall survival between the 2 groups(P>0.05).Conclusion The use of VATS in early NSCLC patients has less trauma,can effectively regulate plasma levels of miR-25,miR-29A,and miR-126,and has little impact on immune function,which is conducive to early postoperative recovery of patients.
万方数据
维普
