The Effect of Bronchoscopic Cryotherapy Combined with Systemic Chemotherapy on Serum Tumor Markers and T Lymphocyte Subsets in Patients with Advanced Lung Cancer
Objective To investigate the effects of bronchoscopic cryotherapy combined with systemic chemotherapy on serum tumor markers and T lymphocyte subsets in patients with advanced lung cancer.Methods 100 patients with advanced lung cancer were selected and divided into 2 groups according to different chemotherapy methods,with 50 patients in each group.The control group received systemic chemotherapy,while the observation group received bronchoscopic cryotherapy combined with systemic chemotherapy.The clinical efficacy,tumor markers[Carcinoembryonic antigen(CEA),neuron specific enolase(NSE),cytokeratin fragment antigen(CYFRA21-1),carbohydrate antigen 19-9(CA199)],T cell subsets[CD4+,CD8+,CD4+/CD8+],quality of life and adverse reactions were compared between the 2 groups.Results The total effective rate of the obser-vation group was 94.00%(48/50),which was statistically different from the 80.00%(40/50)of the control group(P<0.05);After treatment,the CEA levels in the observation group were(25.36±3.81)ng/ml,NSE levels were(28.14±4.03)ng/ml,CYFRA21-1 levels were(12.81±1.04)ng/ml,and CA199 levels were(31.57±3.68)ng/ml,which were lower than the control group's(53.24±6.78)ng/ml,(55.89±8.54)ng/ml,(19.97±1.81)ng/ml,and(50.12±4.60)ng/ml;The CD4+level was(0.52±0.07),and the CD4+/CD8+level was(1.67±0.21),which was higher than the control group(0.41±0.05)and(1.41±0.14);The CD8+level was(0.22±0.04),lower than the control group's(0.30±0.08);The physiological status score,social status score,emotional status score,and functional status score in the Cancer Treatment Function Evaluation System(FACT)were(19.89±6.57),(19.91±6.24),(13.98±7.04),and(15.31±5.40),which were higher than the control group's(17.42±5.61),(16.68±5.91),(12.23±5.60),and(12.69±5.44)scores,with a statistical difference(P<0.05);There was no sta-tistically significant difference in adverse reactions between the 2 groups(P>0.05).Conclusion Bronchoscopic cryotherapy combined with systemic chemotherapy is effective in treating advanced lung cancer patients,effectively improving clinical efficacy and quality of life,reducing serum tumor indicators levels,and being safe and reliable.
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