Microbiological Characteristics and Prognostic Factors in Lung Cancer Patients
Objective To explore the microbiological characteristics and prognostic factors of nosocomial infection in lung cancer patients.Methods 70 patients with lung cancer complicated with hospital infection were selected,and sputum,u-rine,and other samples were collected for bacterial culture.Collect the infection sites and pathogen distribution characteristics of 70 cases of lung cancer combined with hospital infections.Following up for another year,70 patients were divided into a death group(n =19)and a survival group(n =51)based on clinical outcomes.General data such as age and gender were collected to analyze the prognostic factors of lung cancer patients with concurrent infection.Results Respiratory infection was the main type of infection in70 patients with lung cancer complicated with infection,accounting for51.43%(36/70),followed by Urinary tract infection[21.43%(15/70)],oropharyngeal infection[18.57%(13/70)],gastrointestinal infection[5.71%(4/70)].A total of 81 strains of pathogenic bacteria were isolated from sputum,urine,and other samples of 70 patients.Among them,46 strains were Gram negative bacteria,accounting for 56.79%(46/81),mainly Escherichia coli[30.86%(25/81)],Klebsiella pneumon-iae[16.05%(13/81)],and Pseudomonas aeruginosa[7.41%(6/81)];30 strains of Gram positive bacteria,accounting for 37.04%(30/81),mainly Staphylococcus aureus[22.22%(18/81)]and Staphylococcus epidermidis[11.11%(9/81)];5 fungi,accounting for6.17%(5/81).Univariate analysis showed that age,gender,body mass index(BMI),pathological type were not associated with the prognosis of lung cancer patients with nosocomial infection(P>0.05),while albumin levels,septic shock,clinical stage were associated with the patient's prognosis(P<0.05);Multivariate logistic regression analysis showed that albumin<35 g/L(β:3.004,Wald:19.403,95%CI:5.297～76.701),with septic shock(β:2.441,Wald:15.049,95%CI:3.345～39.397),Clinical Phase Ⅲ～Ⅳ(β:2.290,Wald:13.828,95%CI:2.953～32.993)was the main prognostic factor for lung cancer patients with hospital acquired infections(P<0.05).Conclusion Respiratory tract infection is the most common site of hospital infection in lung cancer patients,with Gram negative bacteria as the main pathogen.Albumin<35 g/L,septic shock,clin-ical stages Ⅲ～Ⅳ,etc.are the main factors that affect the prognosis of patients,and clinical attention should be paid to them.
万方数据
维普
