Analysis of the Therapeutic Effect of Ultrasound Intervention Microwave Ablation Combined with Lenvatinib in the Treatment of Primary Small Liver Cancer
Objective To explore the clinical efficacy of ultrasound intervention microwave ablation combined with len-vatinib in the treatment of primary small liver cancer.Methods 88 patients with primary small liver cancer were the study sub-jects.They were divided into the observation group and the control group using a random number table method,with 44 patients in each group.The patients in the control group were treated with ultrasonic intervention microwave ablation,and the observation group was treated with lenvatinib on this basis.The clinical efficacy,serum alpha fetoprotein,liver function[aspartate transami-nase(AST),alanine transaminase(ALT)and albumin(ALB)],adverse reactions and recurrence 1 year after operation were ob-served in the 2 groups.Results The short-term efficacy of the observation group at 9 weeks after surgery was 100%,and there was no statistical significant difference compared to the control group(97.73%)(x2 =1.000,P>0.05).Following up for12 months,the recurrence rate in the observation group was(2.27%)lower than that in the control group(27.27%),with a statisti-cal significant difference(x2 =10.921,P<0.05).After treatment,the AST(38.29±5.23)U/L and ALT(52.21±5.78)U/L in the observation group were statistically significant compared to the AST(45.21±5.38)U/L and ALT(57.25±5.56)U/L in the control group(t =6.121,4.167,P<0.05).The observation group showed statistical significant differences in ALB(29.85±1.61)g/L and AFP(18.21±2.25)μg/L compared to the control group(28.42±1.57)g/L and AFP(23.12±2.12)μg/L(t = 4.244,10.539,P<0.05).The total incidence of adverse reactions during the medication period in the observation group was 11.36%,which improved after intervention.Conclusion Compared to simple ultrasound intervention microwave ablation thera-py,its short-term efficacy is comparable to that of the combination therapy of lenvatinib for primary small liver cancer.However,the combination therapy can improve liver function damage in patients and significantly reduce tumor recurrence rate.
Primary small liver cancerUltrasound intervention microwave ablationLenvatinib
万方数据
维普
