Efficacy of Goserelin Acetate Sustained-release Depot Combined with Radical Prostatectomy for Patients with High-risk Prostate Cancer
Objective To study the efficacy of goserelin acetate sustained-release depot and birucamide tablets com-bined with radical prostatectomy in the treatment of high-risk prostate cancer.Methods 94 patients with high-risk prostate canc-er who were treated were selected as the study subjects and were randomly divided into the observation group(47 cases)and the control group(47 cases).Both groups of patients received radical prostatectomy,and the control group was additionally treated with bicalutamide tablets,and the observation group was additionally given goserelin acetate sustained-release depot combined with bicalutamide tablets.The efficacy,serum prostate specific antigen(PSA),serum testosterone(T),serum dihydrotestosterone(DHT),vascular endothelial growth factor(VEGF),vascular endothelial nitric oxide(NO),urethral recovery(bladder volume,u-rine flow rate,residual urine volume)and incidence rates of adverse reactions were compared between the 2 groups of patients.Results After treatment,the efficacy in the observation group was better than that in the control group(P<0.05).Before treat-ment,there were no significant differences in PSA,T,DHT,VEGF and NO between the 2 groups(P>0.05).After treatment,the levels of PSA,T,DHT,VEGF and NO were decreased in both groups,and the levels in the observation group were lower than those in the control group(P<0.05),and the level of NO was increased in both groups,and the level was higher in the observa-tion group than that in the control group(P<0.05).After treatment,the bladder volume in the observation group was smaller than that in the control group(P<0.05),and the urine flow rate was higher than that in the control group(P<0.05),and the residual urine volume was less than that in the control group(P<0.05).The incidence rates of adverse reactions were close in both groups(P>0.05).Conclusion The application of goserelin acetate sustained-release depot and bicalutamide tablets combined with radical prostatectomy in the treatment of patients with high-risk prostate cancer can enhance the efficacy,reduce the levels of serum PSA and VEGF,and improve the urinary control function,with high safety.
Goserelin acetate sustained-release depotBicalutamide tabletsHigh-risk prostate cancerCognitive function
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