Predictive Value of D-dimer and C Reactive Protein for the Long-term Postoperative Prognosis in Patients with Type Stanford A Aortic Dissection Aneurysm
Predictive Value of D-dimer and C Reactive Protein for the Long-term Postoperative Prognosis in Patients with Type Stanford A Aortic Dissection Aneurysm
Objective To analyze the predictive value of D-dimer(D-D)and C-reactive protein(CRP)in the long-term prognosis of patients with Stanford A Aortic dissection(ADA).Methods 76 patients with chest pain were selected as the study subjects.All patients underwent cardiac ultrasound or aortic CT angiography examination.45 Stanford A type ADA patients were included in the observation group and underwent surgical treatment;31 patients with non Stanford A type ADA were included in the control group.Compare the levels of D-D and CRP within 72 hours of chest pain between the 2 groups.After surgery,the ob-servation group was followed up for 3 years and divided into the death group(n =10)and the survival group(n =35)based on clinical outcomes.D-D and CRP levels were compared between the 2 groups;Additionally,draw a receiver operating curve(ROC)to analyze the clinical value of D-D and CRP alone and in combination in predicting the long-term prognosis of Stanford A type ADA patients.Results The levels of D-D[(1.31±0.35)mg/L]and CRP[(16.59±2.34)mg/L]in the observation group were higher than those in the control group[(0.68±0.13)mg/L,(7.53±1.26)mg/L],with statistical significance(P<0.05);The levels of D-D[(1.78±0.49)mg/L]and CRP[(30.46±4.77)mg/L]in the death group of ADA patients were higher than those in the survival group[(1.03±0.26)mg/L,(13.59±2.36)mg/L],with statistical significance(P<0.05).The ROC results showed that the area under the curve(AUC)[0.909(95%CI:0.823～0.994)]predicted by the combined de-tection of D-D and CRP for long-term prognosis in Stanford A type ADA patients was higher than that predicted by D-D and CRP alone[0.806(95%CI:0.680～0.931),0.840(95%CI:0.727～0.953)].Conclusion The levels of D-D and CRP in the serum of Stanford A type ADA patients are highly expressed,and the higher the expression level,the worse the patient's prognosis.The combination of these 2 indicators can effectively predict the long-term prognosis of patients,and has high clinical application value.
关键词
主动脉夹层动脉瘤/D-二聚体/C反应蛋白/远期预后/预测价值
Key words
Aortic dissection aneurysm/D-dimer/C-reactive protein/Long-term prognosis/Predictive value
维普
万方数据