Changes and Clinical Significance of Serum ProGRP,SCC and Ferritin in Patients with Lung Cancer Before and After Radiotherapy
Objective To explore the changes and clinical significance of serum progastrin-releasing peptide(ProGRP),squamous cell carcinoma antigen(SCC)and ferritin(SF)in patients with lung cancer before and after radiotherapy.Methods A total of 122 patients with non-small cell lung cancer(NSCLC)were enrolled as the study group.According to radiotherapy sensitiv-ity,they were divided into sensitivity group(n =43)and non-sensitivity group(n =79).A total of 70 healthy controls during the same period were enrolled as the control group.The levels of serum ProGRP,SCC and SF in all objects were detected and com-pared,and their diagnostic value for NSCLC was analyzed.The levels of serum ProGRP,SCC and SF in NSCLC patients were com-pared before and after radiotherapy.The changes of serum ProGRP,SCC and SF before and after radiotherapy in NSCLC patients with different radiotherapy sensitivity were analyzed.Results The levels of ProGRP,SCC and SF in the study group were higher than those in the control group(P＜0.05).ROC curves showed that AUC of serum ProGRP combined with SCC and SF in the di-agnosis of NSCLC was 0.926,greater than that of single index(0.784,0.822,0.805,P＜0.05).After radiotherapy,levels of ser-um ProGRP,SCC and SF were decreased in NSCLC patients(P＜0.05).After radiotherapy,levels of serum ProGRP,SCC and SF were decreased in sensitivity group,which were lower than those in non-sensitivity group(P＜0.05).Conclusion The levels of serum ProGRP,SCC and SF increase in NSCLC patients.The combined detection of the three indexes has high diagnostic value for NSCLC,and monitoring their changes is beneficial to evaluate radiotherapy sensitivity of NSCLC patients.
万方数据
维普
