Expression of EGFR,ALK,ROS-1 Genes in Lung Cancer Tissue and Their Relationship with Prognosis
Objective To analyze the expression of epidermal growth factor receptor(EGFR),anaplastic lymphoma ki-nase(ALK),and sarcoma oncogenic factor receptor tyrosine kinase(ROS-1)genes in lung cancer tissue and their relationship with patient prognosis.Methods 75 lung cancer patients were selected,and their cancer tissue and adjacent normal tissue(≥3 cm a-way from the edge of the tumor tissue)were collected.They were divided into the observation group and the control group,and the differences in EGFR,ALK,and ROS-1 expression were measured using immunohistochemistry;Collect age,gender and other data of patients,and analyze the relationship between EGFR,ALK,ROS-1 expression and various pathological characteristics of pa-tients;Follow up for another 3 years to explore the relationship between EGFR,ALK,ROS-1 expression and patient prognosis.Re-sults The positive expression rates of EGFR,ALK,and ROS-1 in the observation group were higher than those in the control group,and the difference was statistically significant(P＜0.05);The positive expression of EGFR,ALK,and ROS-1 was not relat-ed to age,gender,and pathological type(P＞0.05);but related to clinical staging,degree of differentiation,and lymph node me-tastasis(P＜0.05);After 3 years of follow-up,the survival rates of patients with EGFR,ALK,and ROS-1 positive expression were 56.52%(13/23),46.15%(12/26),and 42.11%(8/19),respectively,lower than the 63.46%(33/52),69.39%(34/49),and 67.86%(38/56)of patients with negative expression,with statistically significant differences(P＜0.05).Conclusion EG-FR,ALK,and ROS-1 are abnormally expressed in lung cancer tissue,which are closely related to the clinical stage,differentiation degree,and lymph node metastasis of patients.Positive expression patients have a poor prognosis and should be taken seriously in clinical practice.
万方数据
维普
