The Relationship Between Preoperative Chemokine Levels and Postoperative Recurrence and Metastasis in Cervical Cancer Patients
Objective To explore the relationship between preoperative levels of chemokines and postoperative recur-rence and metastasis of cervical cancer patients.Methods Cervical cancer patients underwent radical hysterectomy+pelvic lymph node dissection were selected as the study subjects.Chemokines[Chemokine receptor 4(CXCR4),Chemokine receptor 7(CCR7),CXC subfamily chemokine 13(CXCL13),CXC subfamily chemokine 16(CXCL16)]were detected before and after sur-gery.After 1 year of follow-up,patients with recurrence and metastasis were included in the occurrence group,patients without re-currence and metastasis were included in the non occurrence group.Results A total of 102 cervical cancer patients were includ-ed,and a 1-year follow-up found that 25 cases(24.51%)experienced postoperative recurrence and metastasis.Before and after surgery,the proportion of high expression of CXCR4 and CCR7 in the occurrence group was higher than that in the non occurrence group,and the levels of CXCL13 and CXCL16 were higher than those in the non occurrence group,with a statistical significant difference(P＜0.05).Chi-squared test Phi coefficient analysis showed that CXCR4 and CCR7 were positively correlated with postoperative recurrence and metastasis of cervical cancer patients(all P＜0.05).Through point2 column correlation analysis,CXCL13 and CXCL16 showed a positive correlation with postoperative recurrence and metastasis in cervical cancer patients(all P＜0.05).ROC curve showed that the AUC of preoperative CXCR4,CCR7,CXCL13 and CXCL16 in predicting postoperative re-currence and metastasis of cervical cancer patients was 0.712,0.711,0.797 and 0.764,respectively.The AUC of combined pre-diction was 0.873,and the combined prediction value was higher.Conclusion Preoperative high expression of CXCR4 and CCR7,high levels of CXCL13 and CXCL16 in patients with cervical cancer,the greater the risk of postoperative recurrence and metastasis.Preoperative detection of chemokine expression in patients can be used as a reference index to predict postoperative re-currence and metastasis in patients with cervical cancer.
万方数据
维普
