The Expression of HE4,CA125,and CEA in the Serum of Ovarian Cancer Patients and Their Relationship with Pathological Characteristics and Prognosis
Objective To investigate the expression of human epididymal protein 4(HE4),carbohydrate antigen 125(CA125),and carcinoembryonic antigen(CEA)in ovarian cancer and their relationship with clinical pathological features and prognosis.Methods 58 patients with ovarian cancer were selected as the observation group,and 58 healthy individuals who un-derwent physical examination during the same period were selected as the control group.All research subjects collected blood to detect levels of HE4,CA125,and CEA.The differences in serum HE4,CA125,and CEA between the 2 groups were compared,and the relationship between HE4,CA125,CEA and pathological features was analyzed.Follow up for 3 years and compare the differences in serum HE4,CA125,and CEA between surviving and deceased patients.Results The serum levels of HE4[(178.52±8.39)pmol/L],CA125[(52.14±5.17)U/ml],and CEA[(18.29±2.14)ng/ml]in the observation group were higher than those in the control group,with statistical significance(P＜0.05);The serum levels of HE4,CA125,and CEA in poorly differentiated,stage Ⅲ、Ⅳ,and lymph node metastatic ovarian cancer patients were higher than those in moderately well differentiated,stage Ⅰ,Ⅱ,and non lymph node metastatic patients,with statistical significance(P＜0.05).58 patients were fol-lowed up for3 years,and 41 survived,with a survival rate of 70.69%(41/58);The serum levels of HE4[(151.69±7.68)pmol/L],CA125[(41.02±4.39)U/ml],and CEA[(13.25±1.69)ng/ml]in the survival group were lower than those in the death group,with statistically significant differences(P＜0.05).Conclusion HE4,CA125,and CEA are highly expressed in the serum of ovarian cancer patients,closely related to tissue differentiation,tumor staging,lymph node metastasis,and prognosis,and can be used for disease and prognosis evaluation.
Ovarian cancerTumor markersHuman epididymal protein 4Carcinoembryonic antigenPathological char-acteristicsClinical prognosis
万方数据
维普
