Expression Levels of GPSM2 and TGF-β1 in Liver Cancer and Their Clinical Significance
Objective To explore the relationship between G protein signaling modulator(GPSM)2,transforming growth factor 1(TGF-β1)proteins and clinicopathological parameters,prognosis in liver cancer tissues.Methods A total of 80 patients with primary liver cancer were enrolled to collect surgically resected liver cancer tissues and normal para-carcinoma tissues.The expression differences of GPSM2 and TGF-β1 in cancer tissues and normal para-carcinoma tissues were detected by immunohisto-chemical staining.The relationship between GPSM2 and TGF-β1 in cancer tissues and clinicopathological parameters,prognosis was analyzed.Results The high expression rates of GPSM2 and TGF-β1 in liver cancer tissues were 71.25%and 82.50%,higher than those in normal para-carcinoma tissues(18.75%,13.75%)(P＜0.05).The high expression rate of GPSM2 was higher in patients with low differentiation(P＜0.05),while high expression rate of TGF-β1 was higher in patients with low differ-entiation and vascular metastasis(P＜0.05).The survival curves showed that cumulative survival rates in patients with low ex-pressions of GPSM2 and TGF-β1 were 77.27%and 85.71%,higher than those with high expressions(47.37%,48.48%)(P＜0.05).Conclusion The high expression rates of GPSM2 and TGF-β1 are high in liver cancer tissues.Their expressions are closely related to differentiation degree.The prognosis was worse in patients with high expressions of GPSM2 and TGF-β1.
Primary liver cancerG protein signaling modulator protein 2Transforming growth factor 1Clinicopathologi-cal parameterPrognosis
万方数据
维普
