Expression and Clinical Significance of HMGB2,MAGE-A9,and MMR Protein in Colorectal Cancer Tissues
Objective To explore the expression of the high-mobility family protein B2(HMGB2),melanoma-associated antigen-A9(MAGE-A9),and DNA mismatch repair gene(MMR)protein in colorectal cancer tissues,and its clinical value in the evaluation of patient prognosis.Methods 52 CRC patients were selected.Tumor samples and adjacent cancer tissue samples were collected from all patients,and the expression levels of HMGB2,MAGE-A9 and MMR protein were detected,and the rela-tionship between the expression of each index and pathological characteristics and prognosis was analyzed.Results Positive ex-pression of HMGB2,MAGE-A9,and MMR was higher in tumor tissue than in adjacent tissues,The difference was statistically sig-nificant(P＜0.05);The number of HMGB2,MAGE-A9 and MMR positive cases,which was higher than those with stage Ⅰ,stage,medium and high differentiation,and no lymph node metastasis,The difference was statistically significant(P＜0.05);Follow-up for 3 years,The survival rate of the 52 patients was 71.15％(37/52);The survival rate of the HMGB2-positive group[61.76％(21/34)]was lower than that of the HMGB2-negative group[88.89％(16/18)],The difference was significant(χ2 =4.219,P =0.040);The survival rate of the MAGE-A9 positive group[58.62％(17/29)]was lower than that of the MAGE-A9 negative group[86.96％(20/23)],The difference was statistical significant(χ2 =5.018,P =0.025);The survival rate of the MMR-posi-tive group[52.00％(13/25)]was lower than that of the MMR-negative group[88.89％(24/27)],The difference was statisti-cally significant(χ2 =8.606,P =0.003).Conclusion The expression of HMGB2,MAGE-A9,and MMR in colorectal cancer is closely related to the tumor stage,differentiation degree,and lymph node metastasis,and the survival rate of patients with different expressions varies greatly,which can be used as an important indicator to evaluate the prognosis.
Colorectal cancerMelanoma-associated antigen-A9High-mobility group protein B2DHA mismatch repair geneClinicopathological featuresPognosis
万方数据
维普
