Analysis of the Predictive Value of Plasma EPCR and Hcy Levels on Thrombosis in Patients with Myeloproliferative Neoplasms
Objective To investigate the predictive value of plasma levels of endothelial cell protein C receptor(EPCR)and homocysteine(Hcy)on thrombosis in patients with myeloproliferative neoplasms(MPN).Methods A total of 137 patients with MPN were selected and categorized into thrombosis group(n =70)and non thrombosis group(n =67)according to whether the thrombosis was present or not.The plasma levels of EPCR and Hcy of the 2 groups were compared,the correlation between the plasma levels of EPCR and Hcy was analyzed,logistic multivariate regression model was constructed to analyze independent risk factors of thrombosis,and the predictive value of plasma levels of EPCR and Hcy on thrombosis was analyzed using the receiver operating characteristic(ROC)curve.Results The plasma level of EPCR in the thrombosis group was significantly lower than that in the non thrombosis group,and the plasma level of Hcy was significantly higher than that in the non thrombosis group(P＜0.05).Spearman correlation analysis showed that the plasma levels of EPCR and Hcy in MPN patients were negatively correlated(P＜0.05).Logistic regression analysis showed that plasma levels of EPCR(≤average)and Hcy(＞average)were independent risk factors for thrombosis in MPN patients(P＜0.05).The Area under the ROC curve(AUC),sensitivity and specificity of com-bined plasma EPCR and Hcy levels in predicting thrombosis in MPN patients were higher than those of single diagnosis of each index.Conclusion Plasma EPCR and Hcy are independent risk factors for thrombosis in MPN patients,the combination of the two indexes has a high predictive value for thrombosis in MPN patients,which is worthy of clinical application.
Endothelial cell protein C receptorHomocysteineBone marrow proliferative tumorThrombosisPredictive value
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