Correlation Between Oral Mucosal Micronucleus Cell Count,Serum and Saliva CYFRA21-1 Levels and Oral Epithelial Carcinogenesis
Objective To investigate the correlation between the number of micronucleus cells in oral mucosa,the level of keratin-19 fragment(CYFRA21-1)in serum and saliva and the progression of oral epithelial carcinogenesis.Methods A re-gression analysis was conducted on 102 patients with oral diseases,including 57 cases of tongue leukoplakia(leukoplakia group)and 45 cases of oral squamous cell carcinoma(squamous cell carcinoma group).Another 44 individuals with normal oral mucosa were selected for the same period examination(normal group),and the oral mucosal micronucleus cell count and CYFRA21-1 lev-els in serum and saliva of each group were compared.The relationship between each indicator and the progression of oral epithelial cancer was analyzed.Results Oral mucosal micronucleus cell count and serum and saliva CYFRA21-1 expression levels in 3 groups:squamous cell carcinoma grou P＞leukoplakia grou P＞normal group,and the difference among the 3 groups was statistical-ly significant(P＜0.05);the difference between the each 2 groups was statistically significant(P＜0.05).The micronucleus cell count of oral mucosa and the expression levels of CYFRA21-1 in serum and saliva in the advanced group of squamous cell carci-noma patients were higher than those in the early group,and the difference between the 2 groups was statistically significant(P＜0.05).According to univariate and multivariate statistical analysis,differentiation,lymph node metastasis,oral mucosal micronu-cleus cell count,serum CYFRA21-1,and salivary CYFRA21-1 were all independent risk factors for cancer progression in oral squamous cell carcinoma(P＜0.05).The sensitivity of single detection of oral mucosal micronucleus cell count,serum CY-FRA21-1,and saliva CYFRA21-1 was 84.0%,72.0%,and 64.0%,respectively,and the specificity was 78.9%,68.4%,and 73.7%;the sensitivity and specificity of combined detection were 88.0%and 84.2%,respectively,with the highest sensitivity and specificity of combined detection and the best diagnostic efficacy for early squamous cell carcinoma and precancerous lesions.Conclusion The count of oral mucosal micronucleus cells and CYFRA21-1 in serum and saliva are closely related to the disease progression of oral squamous cell carcinoma,which can help predict the diagnosis of early oral squamous cell carcinoma and pre-cancerous lesions.
Oral epithelial carcinogenesisMucosaMicronucleus cell countCytokeratin 19 fragment
万方数据
维普
