miR-9、miR-194在鼻咽癌组织中的表达及与其预后的关系

Expression of miR-9 and miR-194 in Nasopharyngeal Carcinoma and Their Relationship with Prognosis

陈璀璀 ¹李永磊 ¹芦二永¹

扫码查看

作者信息

1. 471003 河南科技大学第一附属医院
折叠

摘要

目的探讨miR-9、miR-194 在鼻咽癌组织中的表达水平变化及其预后价值.方法选取鼻咽癌患者 76例,随访3～36 个月,根据预后情况分为死亡组(n =21 例),存活组(n =55 例).统计比较miR-9、miR-194 不同表达水平的鼻咽癌患者的临床资料,以及不同预后的鼻咽癌患者miR-9、miR-194 表达水平,采用Logistic回归分析鼻咽癌患者预后相关影响因素.结果 76 例鼻咽癌患者miR-9 高表达29 例,低表达47 例,miR-194 高表达35 例,低表达 41 例;miR-9、miR-194 低表达患者的临床分期为Ⅲ～Ⅳ期、肿瘤分期为T3～T4 期、组织分化程度为高中分化、发生淋巴结转移及远处转移的比例高于miR-9、miR-194 高表达患者(P＜0.05);两组临床分期、肿瘤分期、组织分化程度、淋巴结转移及远处转移情况、miR-9 表达水平、miR-194 表达水平比较差异显著(P＜0.05);临床分期、肿瘤分期、组织分化程度、淋巴结转移及远处转移情况、miR-9 表达水平、miR-194 表达水平为鼻咽癌患者预后影响因素(P＜0.05).结论 miR-9、miR-194 低表达与鼻咽癌患者恶性生物学行为进程及预后有关,该研究提示miR-9、miR-194 可能是鼻咽癌预后评估的有效分子靶点,值得临床进一步深入探究.

Abstract

Objective To investigate the changes of expression levels of miR-9 and miR-194 in nasopharyngeal carcino-ma and their prognostic value.Methods 76 patients with nasopharyngeal carcinoma were followed up for 3 to 36 months and di-vided into death group(n =21 cases)and survival group(n =55 cases)according to the prognosis.The clinical data of nasopharyn-geal carcinoma patients with different expression levels of miR-9 and miR-194,as well as the expression levels of miR-9 and miR-194 in nasopharyngeal carcinoma patients with different prognosis were statistically compared.Logistic regression was used to ana-lyze the prognostic factors of nasopharyngeal carcinoma patients.Results In 76 patients with nasopharyngeal carcinoma,29 cases showed high expression of miR-9,47 cases showed low expression,35 cases showed high expression of miR-194 and 41 cases showed low expression.The clinical stages of patients with low expression of miR-9 and miR-194 areⅢ～Ⅳ,and the tumor sta-ges are T3～T4.The proportion of patients with high differentiation,lymph node metastasis and distant metastasis was higher than that of patients with high expression of miR-9 and miR-194(P＜0.05).There were significant differences in clinical stage,tumor stage,tissue differentiation,lymph node metastasis and distant metastasis,miR-9 expression level and miR-194 expression level between the 2 groups(P＜0.05);Clinical stage,tumor stage,degree of tissue differentiation,lymph node metastasis and dis-tant metastasis,miR-9 expression level and miR-194 expression level were the prognostic factors of NPC patients(P＜0.05).Conclusion The low expression of miR-9 and miR-194 is related to the malignant biological behavior process and prognosis of nasopharyngeal carcinoma patients.This study suggests that miR-9 and miR-194 may be effective molecular targets for prognosis evaluation of nasopharyngeal carcinoma,which is worthy of further clinical exploration.

关键词

鼻咽癌/微RNAs/预后/临床分期/组织分化程度/肿瘤分期/淋巴结转移

Key words

Nasopharyngeal carcinoma/Micro RNAs/Prognosis/Clinical staging/Degree of tissue differentiation/Tumor staging/Lymph node metastasis

引用本文复制引用

出版年

2024

实用癌症杂志

江西省肿瘤医院　江西省肿瘤研究所

实用癌症杂志

影响因子：1.241

ISSN：1001-5930

参考文献量21

段落导航