Expression of miR-9 and miR-194 in Nasopharyngeal Carcinoma and Their Relationship with Prognosis
Objective To investigate the changes of expression levels of miR-9 and miR-194 in nasopharyngeal carcino-ma and their prognostic value.Methods 76 patients with nasopharyngeal carcinoma were followed up for 3 to 36 months and di-vided into death group(n =21 cases)and survival group(n =55 cases)according to the prognosis.The clinical data of nasopharyn-geal carcinoma patients with different expression levels of miR-9 and miR-194,as well as the expression levels of miR-9 and miR-194 in nasopharyngeal carcinoma patients with different prognosis were statistically compared.Logistic regression was used to ana-lyze the prognostic factors of nasopharyngeal carcinoma patients.Results In 76 patients with nasopharyngeal carcinoma,29 cases showed high expression of miR-9,47 cases showed low expression,35 cases showed high expression of miR-194 and 41 cases showed low expression.The clinical stages of patients with low expression of miR-9 and miR-194 areⅢ～Ⅳ,and the tumor sta-ges are T3～T4.The proportion of patients with high differentiation,lymph node metastasis and distant metastasis was higher than that of patients with high expression of miR-9 and miR-194(P＜0.05).There were significant differences in clinical stage,tumor stage,tissue differentiation,lymph node metastasis and distant metastasis,miR-9 expression level and miR-194 expression level between the 2 groups(P＜0.05);Clinical stage,tumor stage,degree of tissue differentiation,lymph node metastasis and dis-tant metastasis,miR-9 expression level and miR-194 expression level were the prognostic factors of NPC patients(P＜0.05).Conclusion The low expression of miR-9 and miR-194 is related to the malignant biological behavior process and prognosis of nasopharyngeal carcinoma patients.This study suggests that miR-9 and miR-194 may be effective molecular targets for prognosis evaluation of nasopharyngeal carcinoma,which is worthy of further clinical exploration.
Nasopharyngeal carcinomaMicro RNAsPrognosisClinical stagingDegree of tissue differentiationTumor stagingLymph node metastasis
万方数据
维普
