摘要
目的 比较乳腺癌患者保乳术中放疗与术后全乳放疗的疗效、安全性及美容效果.方法 选择98 例乳腺癌患者,均行保乳术.依照入院顺序分成A组(n =49)、B组(n =49),分别实施术后全乳放疗、术中放疗.比较两组并发症情况、美容效果、肿瘤标志物水平、远期预后.结果 B组并发症发生率为 8.16%,显著较A组的 24.49%低(P＜0.05);B组美容优良率为89.80%,明显较A组的65.31%高(P＜0.05);术后8 周,两组血清糖类抗原(carbohydrate anti-gen,CA)125、癌胚抗原(carcinoembryonic antigen,CEA)水平均低于术前(P＜0.05),组间比较差异无统计学意义(P＞0.05);B组局部复发、转移、生存率分别为6.12%、0.00%与100.00%,与A组的2.04%、2.04%、97.96%比较差异无统计学意义(P＞0.05).结论 乳腺癌患者保乳术中放疗的远期效果和术后全乳放疗相当,但术中放疗可减少并发症的发生,提高乳房美容效果.
Abstract
Objective To compare the efficacy,safety and cosmetic effect of intraoperative radiotherapy and postopera-tive whole breast radiotherapy for breast cancer patients.Methods A total of 98 patients with breast cancer were collected for breast conserving surgery.They were divided into group A(n =49)and group B(n =49)according to the order of admission,and implemented postoperative whole breast radiotherapy and intraoperative radiotherapy respectively.The complications,cosmetic effects,tumor marker levels,and long-term prognosis were compared between the 2 groups.Results The incidence of complica-tions in group B was 8.16%,which was obviously lower than group A,24.49%(P＜0.05);the excellent and good cosmetic rate in group B was 89.80%,which was obviously higher than 65.31%in group A(P＜0.05);at8 weeks after surgery,the levels of serum carbohydrate antigen(CA)125 and carcinoembryonic antigen(CEA)in both groups were lower than before surgery(P＜0.05),while there was no statistically obvious difference between the groups(P＞0.05);the local recurrence,metastasis,and survival rates in group B were 6.12%,0.00%,and 100.00%,respectively,and there was no statistically significant difference compared to group A,2.04%,2.04%,and 97.96%(P＞0.05).Conclusion The long-term effect of intraoperative radiotherapy in breast conserving surgery for breast cancer patients is similar to that of postoperative whole breast radiotherapy,but intraopera-tive radiotherapy can reduce the occurrence of complications and improve the cosmetic effect of breast.
基金项目
河南省2021年科技发展计划项目(212102310693)
维普
万方数据