Efficacy and Safety of CalliSpheres Drug-eluting Beads During DEB-TACE in the Treatment of Hepatocellular Carcinoma
Objective To observe the efficacy and safety of CalliSpheres drug-eluting beads during drug-eluting bead-based transcatheter arterial chemoembolization(DEB-TACE)for massive hepatocellular carcinoma(HCC).Methods 78 patients with HCC were selected and divided into the study group(n =38)and the conventional group(n =40)according to treatment methods.The study group was given CalliSpheres drug-eluting beads during DEB-TACE while the conventional group was treated with traditional transcatheter arterial chemoembolization(TACE).The clinical efficacy after 3 months of treatment,changes in bio-chemical indicators[albumin(ALB),serum total bilirubin(TBIL),alanine aminotransferase(ALT)]before and after treatment,changes in tumor markers[serum alpha-fetoprotein(AFP),abnormal prothrombin(APT)]before and after treatment and occur-rence of side-effect after treatment were compared between the 2 groups.Results The clinical efficacy in the study group was sig-nificantly better than that in the conventional group(P＜0.05).Before treatment,there were no significant differences in the lev-els of ALB,TBIL and ALT between the 2 groups(P＞0.05).After treatment,the ALB level in the 2 groups of patients was signifi-cantly increased compared with that before treatment,and the level in study group was significantly higher than that in convention-al group(P＜0.05).The levels of TBILand ALTinthe2 groups were significantly decreased compared with those before treat-ment,and the levels in study group were significantly lower compared to conventional group(P＜0.05).The scores of behavioral toxicity,nervous system and cardiovascular system in the study group were significantly lower than those in the conventional group(P＜0.05),but there were no significant differences in the scores of laboratory examination,vegetative nervous system and others between the 2 groups(P＞0.05).Conclusion The application of CalliSpheres drug-eluting beads during DEB-TACE can effec-tively enhance the clinical efficacy of interventional therapy for hepatocellular carcinoma,and can effectively inhibit the expres-sions of tumor markers while improving the liver function,and it has good safety and certain clinical application value.
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