Correlation Between Albumin/alkaline Phosphatase and Prognosis of Patients with Cervical Cancer Underwent Chemotherapy
Objective To investigate the relationship between albumin(ALB)/alkaline phosphatase(ALP)and the prog-nosis of patients with cervical cancer who underwent chemotherapy.Methods Retrospective analysis was conducted to collect clinical data of 120 cervical cancer patients who underwent chemotherapy treatment.All patients received 4 cycles of cisplatin combined with paclitaxel chemotherapy.According to the efficacy evaluation results on the 30th day after the completion of the chemotherapy cycle,patients were divided into a good prognosis group(n =101)and a poor prognosis group(n =19).The baseline data such as age,course of disease,type of disease and stage of disease were compared between the 2 groups.The ALB,ALP and other laboratory indexes measured within 1 week before chemotherapy were compared,and the ALB/ALP value was calculated.The relationship between ALB/ALP and the prognosis of patients with cervical cancer chemotherapy was analyzed by point two column correlation analysis and receiver operating curve(ROC).Results The tumor diameter,ALP,and the proportion of stages Ⅲ and IVA in the poor prognosis group were significantly higher than those in the good prognosis group,while ALB and ALB/ALP were significantly lower than those in the good prognosis group,with a statistically significant difference(P＜0.05).Through point two column correlation analysis,ALB,ALP,ALB/ALP were associated with poor prognosis in cervical cancer patients under-went chemotherapy(P＜0.05).The receiver operating curve(ROC)was drawn.The results showed that the area under the curve(AUC)values of ALB,ALP and ALB/ALP in predicting the poor prognosis of patients with cervical cancer chemotherapy were 0.804,0.215 and 0.862,respectively,and ALB/ALP had the highest predictive value.Conclusion There is a negative correla-tion between ALB/ALP and poor prognosis in cervical cancer patients underwent chemotherapy.The lower the value,the higher the likelihood of poor prognosis.
万方数据
维普
