摘要
目的 探讨白蛋白(ALB)/碱性磷酸酶(ALP)与宫颈癌化疗患者预后的相关性.方法 回顾性收集 120例宫颈癌患者临床资料,所有患者接受4 个周期的顺铂联合紫杉醇化疗.根据化疗周期完成后第30 天时疗效评定结果将患者分为预后良好组(n =101)与预后不良组(n =19).对比2 组患者年龄、病程、疾病类型、疾病分期等基线资料;对比化疗前1 周内所测的ALB、ALP及其他实验室指标,并计算ALB/ALP值.通过点二列相关性分析和受试者工作曲线(ROC)分析ALB/ALP与宫颈癌化疗患者预后的关系.结果 预后不良组肿瘤直径、ALP水平高于预后良好组,Ⅲ期与ⅣA期患者占比显著高于预后良好组,ALB、ALB/ALP显著低于预后良好组,差异有统计学意义(P＜0.05).经点二列相关性分析,ALB、ALP、ALB/ALP与宫颈癌化疗患者不良预后发生有关(P＜0.05).绘制受试者工作曲线(ROC),结果显示,ALB、ALP、ALB/ALP预测宫颈癌化疗患者不良预后的曲线下面积(AUC)值分别为 0.804、0.215、0.862,ALB/ALP预测价值最高.结论 ALB/ALP与宫颈癌化疗患者不良预后间呈负相关,其值越低,不良预后发生可能性越高.
Abstract
Objective To investigate the relationship between albumin(ALB)/alkaline phosphatase(ALP)and the prog-nosis of patients with cervical cancer who underwent chemotherapy.Methods Retrospective analysis was conducted to collect clinical data of 120 cervical cancer patients who underwent chemotherapy treatment.All patients received 4 cycles of cisplatin combined with paclitaxel chemotherapy.According to the efficacy evaluation results on the 30th day after the completion of the chemotherapy cycle,patients were divided into a good prognosis group(n =101)and a poor prognosis group(n =19).The baseline data such as age,course of disease,type of disease and stage of disease were compared between the 2 groups.The ALB,ALP and other laboratory indexes measured within 1 week before chemotherapy were compared,and the ALB/ALP value was calculated.The relationship between ALB/ALP and the prognosis of patients with cervical cancer chemotherapy was analyzed by point two column correlation analysis and receiver operating curve(ROC).Results The tumor diameter,ALP,and the proportion of stages Ⅲ and IVA in the poor prognosis group were significantly higher than those in the good prognosis group,while ALB and ALB/ALP were significantly lower than those in the good prognosis group,with a statistically significant difference(P＜0.05).Through point two column correlation analysis,ALB,ALP,ALB/ALP were associated with poor prognosis in cervical cancer patients under-went chemotherapy(P＜0.05).The receiver operating curve(ROC)was drawn.The results showed that the area under the curve(AUC)values of ALB,ALP and ALB/ALP in predicting the poor prognosis of patients with cervical cancer chemotherapy were 0.804,0.215 and 0.862,respectively,and ALB/ALP had the highest predictive value.Conclusion There is a negative correla-tion between ALB/ALP and poor prognosis in cervical cancer patients underwent chemotherapy.The lower the value,the higher the likelihood of poor prognosis.
维普
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