摘要
目的 探讨星状神经节阻滞联合吗啡对晚期癌症患者癌性疼痛及抗肿瘤因子的影响.方法 选取晚期癌症患者84 例,按随机数字表法分为2 组,各42 例.对照组予以吗啡治疗,观察组在对照组基础上加用星状神经节阻滞治疗,均于治疗30d后评价疗效.比较2 组疼痛评分、吗啡使用量、自我效能感、抗肿瘤因子水平、疼痛因子水平及不良反应.结果 观察组治疗15 d、30 d时VAS评分及吗啡使用量为(2.32±0.24)分、(1.89±0.24)分和(38.96±3.25)mg、(42.36±3.37)mg,低于对照组,差异有统计学意义(P＜0.05).观察组治疗后PSE评分、FSE评分、CSE评分以及IFN-γ、TNF-α分别为(55.48±4.63)分、(52.47±4.72)分、(51.89±4.53)分、(20.36±3.69)pg/mL、(4.97±0.89)pg/mL,均高于对照组,差异有统计学意义(P＜0.05);观察组治疗后 PGE2、5-HT、SP 为(62.35±5.28)pg/mL、(0.33±0.08)pg/mL、(53.65±5.02)pg/mL,均低于对照组,差异有统计学意义(P＜0.05).2 组不良反应相比,差异无统计学意义(P＞0.05).结论 星状神经节阻滞联合吗啡可提高晚期癌症患者镇痛效果,减少疼痛因子分泌,减轻疼痛对患者自我效能的影响,且还可提升IFN-γ、TNF-α水平,安全可靠.
Abstract
Objective To investigate the effects of stellate ganglion block combined with morphine on cancer pain and anti-tumor factors in advanced cancer patients.Methods 84 patients with advanced cancer were selected and randomly divided into 2 groups with 42 cases each.The control group was treated with morphine,while the observation group was treated with stel-late ganglion block in addition to the control group.The efficacy was evaluated 30 days after treatment.Compare the pain scores,morphine use,self-efficacy,anti-tumor factor levels,pain factor levels,and adverse reactions between the 2 groups.Results The VAS score and morphine usage in the observation group were(2.32±0.24)points,(1.89±0.24)points,(38.96±3.25)mg,and(42.36±3.37)mg at the 15th and 30th days of treatment,which were lower than those in the control group,with statistically significant differences(P＜0.05).In the observation group,PSE score,FSE score,CSE score,and IFN-γ、TNF-α scores after treatment were(55.48±4.63),(52.47±4.72),(51.89±4.53),(20.36±3.69)pg/mL,and(4.97±0.89)pg/mL,respec-tively,which were higher than those of the control group,with statistically significant differences(P＜0.05);After treatment,the PGE2,5-HT,and SP levels in the observation group were(62.35±5.28)pg/mL,(0.33±0.08)pg/mL,and(53.65±5.02)pg/mL,which were significantly lower than those in the control group(P＜0.05).There was no statistically significant difference in adverse reactions between the 2 groups(P＞0.05).Conclusion Stellate ganglion block combined with morphine can improve the analgesic effect of advanced cancer patients,reduce the secretion of pain factors,alleviate the impact of pain on self-efficacy,and also enhance IFN-γ、TNF-α Horizontal,safe and reliable.
维普
万方数据