Effects of Stellate Ganglion Block Combined with Morphine on Cancer Pain and Anti Tumor Factor Levels in Patients with Advanced Cancer
Objective To investigate the effects of stellate ganglion block combined with morphine on cancer pain and anti-tumor factors in advanced cancer patients.Methods 84 patients with advanced cancer were selected and randomly divided into 2 groups with 42 cases each.The control group was treated with morphine,while the observation group was treated with stel-late ganglion block in addition to the control group.The efficacy was evaluated 30 days after treatment.Compare the pain scores,morphine use,self-efficacy,anti-tumor factor levels,pain factor levels,and adverse reactions between the 2 groups.Results The VAS score and morphine usage in the observation group were(2.32±0.24)points,(1.89±0.24)points,(38.96±3.25)mg,and(42.36±3.37)mg at the 15th and 30th days of treatment,which were lower than those in the control group,with statistically significant differences(P＜0.05).In the observation group,PSE score,FSE score,CSE score,and IFN-γ、TNF-α scores after treatment were(55.48±4.63),(52.47±4.72),(51.89±4.53),(20.36±3.69)pg/mL,and(4.97±0.89)pg/mL,respec-tively,which were higher than those of the control group,with statistically significant differences(P＜0.05);After treatment,the PGE2,5-HT,and SP levels in the observation group were(62.35±5.28)pg/mL,(0.33±0.08)pg/mL,and(53.65±5.02)pg/mL,which were significantly lower than those in the control group(P＜0.05).There was no statistically significant difference in adverse reactions between the 2 groups(P＞0.05).Conclusion Stellate ganglion block combined with morphine can improve the analgesic effect of advanced cancer patients,reduce the secretion of pain factors,alleviate the impact of pain on self-efficacy,and also enhance IFN-γ、TNF-α Horizontal,safe and reliable.
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