The Diagnostic Value of Postoperative Lipid Metabolism in Early Anastomotic Leakage After Radical Gastrectomy for Gastric Cancer
Objective To explore the diagnostic value of postoperative blood lipid indicators in early anastomotic leakage after radical gastrectomy for gastric cancer.Methods The clinical data of 41 patients with anastomotic leakage within 10 days af-ter radical gastrectomy were retrospectively collected and included in the occurrence group.The clinical data of patients without anastomotic leakage within 10 days after radical gastrectomy in the same period were collected and included in the non-occurrence group.All patients completed the examination of blood lipid indicators[total cholesterol(TC),triglyceride(TG),low density lipo-protein cholesterol(LDL-C),high density lipoprotein cholesterol(HDL-C)]1 day after surgery.The general baseline data of the 2 groups were statistically analyzed.The early postoperative blood lipid indexes of the 2 groups were compared,and the receiver op-erating characteristic(ROC)curve was drawn to analyze the predictive value of postoperative blood lipid indexes for anastomotic leakage after radical gastrectomy.Results The proportion of patients with type 2 diabetes and hypoproteinemia in the occurrence group was higher than that in the non occurrence group,with a statistically significant difference(P＜0.05).At1 dayaftersurger-y,the serum TC and LDL-C levels in the occurrence group were higher than those in the non occurrence group,with a statistically significant difference(P＜0.05).The preliminary results showed that type2 diabetes,hypoproteinemia,high serum TC and LDL-C in early postoperative period were associated with anastomotic leakage after radical gastrectomy.The results of ROC drawing showed that the area under the curve(AUC)of serum TC and LDL-C to predict the occurrence of anastomotic leakage after radical gastrectomy in patients with gastric cancer 1 day after surgery was≥0.7,which had certain predictive value.Conclusion There is a certain relationship between the high levels of serum TC and LDL-C in patients with gastric cancer undergoing radical surgery in the early postoperative stage and the occurrence of anastomotic leakage.Early combined detection of these 2 levels can be used to predict the risk of anastomotic leakage after gastric cancer radical surgery.
Gastric cancerRadical gastrectomy for gastric cancerTotal cholesterolLow density lipoprotein cholesterol
万方数据
维普
