Clinical Effect of Laparoscopic Radical Resection on Tumor Markers and Oxidative Stress Response
Objective To study the clinical effect of laparoscopic radical treatment in gastric cancer on tumor markers and oxidative stress levels.Methods 78 gastric cancer patients were selected and divided into 2 groups with 39 patients each.The control group was treated with radical laparotomy and the observation group with laparoscopic radical resection.The surgical conditions,tumor markers,oxidative stress level,inflammation level,and the occurrence of complications were compared between the2 groups.Results The operation,exhaust,and hospitalization duration in the observation group were(221.52±13.25)min,(1.52±0.39)d,(10.98±2.04)d,which was shorter than(257.63±14.13)min,(2.38±0.43)d,and(14.39±2.18)d of the control group,Bleeding volume was(209.63±12.43)ml,which was lower than(296.87±15.38)ml of the control group,there had statistical difference(P＜0.05);The observed postoperative levels of carcinomoembryonic antigen(CEA),sugar antigen 199(CA199),and sugar antigen 125(CA125)were(14.63±2.08)ng/ml,(34.35±3.82)U/ml,(3 7.25±3.96)U/ml,which was lower than(18.8.28±2.24)ng/ml,(40.16±4.02)U/ml,(4 2.58±4.23)U/ml of the control group,there had statistical difference(P＜0.05);The levels of postoperative superoxide digidase(SOD)and glutathione peroxidase(GSH-Px)were(67.85±6.14)U/ml,(218.96±23.52)pg/ml,which were higher than those in the control group(55.73±6.05)U/ml,(186.74±19.68)pg/ml,The level of malondialdehyde(MDA)was(25.37±3.19)U/L,which were lower than the control group(30.82±3.57)U/L,there had statistical difference(P＜0.05);The postoperative levels of C reactive protein(CRP),interleukin-6(IL-6)and tumor necrosis factor-α(TNF-α)were(20.41±2.86)mg/L,(25.96±3.12)ng/L,(69.85±5.37)ng/L,which were lower than(26.93±3.12)mg/L,(31.52±3.45)ng/L,and(78.52±6.05)ng/L of the control group,The complication rate was lower than that of the control group,there had statistical difference(P＜0.05).Conclusion Radical laparoscopy is better than open surgery,which can reduce CA199,CEA and CA125 levels,reduce body trauma,inhibit oxidative stress,prevent inflammatory fac-tor activation and reduce complications.
万方数据
维普
