The Relationship Between Nerve Invasion and Clinicopathological Features and Prognostic Expression of Gastric Cancer
Objective To analyze the relationship between nerve infiltration(PNI)and other clinicoppathological prog-nostic expression of gastric cancer(GC).Methods Clinical data of 274 GC patients were retrospectively analyzed and divided into PNI positive(n =65)and PNI negative(n =209)in the presence of PNI,and the relationship between PNI and clinicopatho-logical factors in GC patients were analyzed.Results Positive PNI was significantly correlated with the differentiation degree,TNM stage,T stage,N stage,and vascular cancer plugs in GC patients(P＜0.05);The logistic regression analysis revealed that low differentiation degree,TNM stage was stage Ⅲ,T stage was T4 stage,N stage was N3 stage,and vascular cancer thrombolysis were the risk factors affecting PNI positivity in GC patients(P＜0.05);The prognosis of GC patients was significantly associated with tumor diameter,TNM stage,vascular and cancer embolus,and PNI(P＜0.05);The logistic regression analysis revealed that tumor diameter＞5 cm,TNM stage,vascular cancer thrombus,and positive PNI were the risk factors affecting the prognosis of GC patients(P＜0.05).Conclusion There is a correlation between PNI and clinicopathological factors such as differentiation de-gree and TNM stage of GC patients,and GC patients with PNI often have poor prognosis and low 5-year survival rate.PNI can be used as an important reference index to diagnose and evaluate GC prognosis,and provide new ideas for clinical treatment.
万方数据
维普
