摘要
目的 探讨影响脑胶质瘤患者术后远期预后的相关因素.方法 选取脑胶质瘤手术患者94 例,对患者一般资料情况进行分析,评价胶质瘤患者术后远期预后的影响因素.结果 术后随访3 个月～5 年,94 例患者中1、2、3、4、5 年生存率分别为79.79%(75/94)、58.51%(55/94)、40.43%(38/94)、30.85%(29/94)、22.34%(21/94),中位生存时间为29 个月.预后不良组病理分级Ⅳ级、术前卡氏功能状态(KPS)评分＜70 分、肿瘤大小≥6 cm、部分切除、无放化疗结合、术前无癫痫发作、有瘤周水肿占比高于预后良好组(P＜0.05).多因素回归分析显示:病理分级、术前KPS评分、肿瘤大小、切除程度、放化疗结合、术前癫痫发作、瘤周水肿为脑胶质瘤患者术后远期预后影响因素(P＜0.05).结论 病理分级、术前KPS评分、肿瘤大小、切除程度、放化疗结合、术前癫痫发作、瘤周水肿为脑胶质瘤患者术后远期预后的影响因素,临床需积极采取合理措施,提高手术治疗效果,改善疾病预后.
Abstract
Objective To explore the factors related to the long-term prognosis of patients with brain glioma after surger-y.Methods 94 patients with glioma were selected and their general data were analyzed to evaluate the influencing factors of long-term prognosis of glioma patients after surgery.Results The patients were followed up for 3 months to 5 years,The 1-,2-,3-,4-and 5-year survival rates of 94 patients were 79.79%(75/94),58.51%(55/94),40.43%(38/94),30.85%(29/94),and22.34%(21/94),respectively.The median survival time was29 months;The percentage of pathological grade Ⅳ,preopera-tive KPS score＜70,tumor size≥6 cm,partial resection,no combination of radiotherapy and chemotherapy,no seizure before op-eration and peritumoral edema in poor prognosis group was higher than that in good prognosis group(P＜0.05).Multivariate re-gression analysis showed that pathological grade,preoperative KPS score,tumor size,resection degree,combination of radiotherapy and chemotherapy,preoperative seizure and peritumoral edema were the influencing factors for the long-term prognosis of patients with glioma after operation(P＜0.05).Conclusion Pathological grading,preoperative KPS score,tumor size,degree of resec-tion,combination of radiotherapy and chemotherapy,preoperative epileptic seizures,and peritumoral edema are the long-term prog-nostic factors for patients with glioma.Reasonable measures should be taken actively to improve the surgical treatment effect and disease prognosis.
维普
万方数据