Relationship Between HRD1,P53,HER2 and Clinicopathological Features of Invasive Ductal Carcinoma of Breast
Objective To study the relationship between HRD1,P53,HER2 and clinicopathological features of invasive ductal carcinoma of the breast.Methods 82 patients with breast cancer diagnosed and treated were selected as the research ob-jects.The levels of HRD1,P53 and HER2 in adjacent and cancerous tissues were compared by immunohistochemical elivision two-step method,and the correlation between HRD1,P53 and HER2 and clinicopathological features of breast invasive ductal car-cinoma was analyzed.Results The positive expression rates of HRD1(χ2 =5.502,P =0.019),P53(χ2 =6.552,P =0.011)and HER2(χ2 = 5.512,P = 0.023)in cancer tissues were obvious higher than paracancerous tissues;there were significant differences in the expression levels of P53,HRD1 and HER2 in invalids with different tumor diameter,vascular invasion,TNM stage and lymph node metastasis(P<0.05);through correlation analysis,the expression levels of HRD1,P53 and HER2 in inva-lids with different tumor diameter,vascular invasion,TNM stage and lymph node metastasis were statistically significant(P<0.05)Tumor diameter,vascular invasion,TNM stage and lymph node metastasis were positively correlated with HRD1,P53 and HER2.Conclusion HRD1,P53,HER2 are significantly correlated with the clinicopathological features of breast invasive ductal carcinoma,which can be used as an important target for future treatment.
万方数据
维普
