Clinical Observation of Midazolam Administered Before Anesthesia Induction in Patients Underwent Radical Thyroidectomy for Thyroid Cancer
Objective To analyze the clinical effect of midazolam administered before anesthesia induction in patients underwent radical thyroidectomy for thyroid cancer.Methods 80 patients who underwent radical thyroidectomy for thyroid cancer were selected and randomly divided into 2 groups,each with 40 cases.The control group received routine anesthesia induction dur-ing surgery,while the observation group received midazolam before anesthesia induction on the basis of the control group.Compare the anesthesia effect,stress response indicators[adrenaline(E),norepinephrine(NE),interleukin-10(IL-10)],awakening quali-ty,anesthetic dosage,and adverse reactions between the 2 groups.Results There was no statistically significant difference in the bispectral index(BIS)between the 2 groups before anesthesia induction(T0),1 minute after induction(T1),2 hours after induc-tion(T5),and at awakening(T6)(P>0.05);After 3 minutes of induction(T2),during tracheal intubation(T3),and 1 hour after induction(T4),the BIS of the observation group was lower than that of the control group,with statistical differences(P<0.05).Before surgery,there was no statistically significant difference in E,NE,and IL-10 between the 2 groups(P>0.05);At 6 hours after surgery,the E,NE,and IL-10 levels in the observation group were lower than those in the control group,with statistical differ-ences(P<0.05).The observation group had shorter awakening,eye opening,and extubation times compared to the control group.The total dosage of propofol and remifentanil was lower than the control group,and the incidence of adverse reactions was lower than the control group,with a statistical difference(P<0.05).Conclusion Midazolam administered before anesthesia induction in thyroid cancer radical surgery can enhance anesthesia efficacy,control stress reactions,reduce anesthetic dosage,improve awak-ening quality,and reduce the incidence of adverse reactions.It has high clinical application value and can be vigorously promoted.
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