Clinical Characteristics and Prognostic Factors of Acute Monocytic Leukemia
Objective To analyze the clinical characteristics and prognostic factors of acute monocytic leukemia(AML M5)patients.Methods A retrospective analysis was conducted on 97 AML M5 patients who were followed up for 1 year.They were divided into a good prognosis group and a poor prognosis group based on their clinical outcomes(death or survival).Data on age,gender,and other factors of all patients were collected,and a multivariate logistic regression analysis model was used to ana-lyze the relevant factors affecting the prognosis of AML M5 patients.Results Among the 97 patients,a total of 51(52.58%)were diagnosed with fever,followed by18(18.56%)with dizziness and fatigue,14(14.43%)with gingival swelling and pain,and oral ulcers;The degree of bone marrow hyperplasia was mainly classified as extremely active in47 cases(48.45%),followed by significantly active in20 cases(20.62%),active in17 cases(17.53%),decreased in 9 cases(9.28%),and extremely re-duced in 4 cases(4.12%).During a one-year follow-up,80 out of 97 patients survived(82.47%)and 17 died(17.53%);Uni-variate analysis showed that age,presence or absence of minimal residual lesions,functional state score(PS),and initial white blood cell count were associated with the prognosis of AML M5 patients(P<0.05).Multivariate logistic regression analysis showed that age≥60 years old,minimal residual lesions,PS score≥2 points,and white blood cell count>50×109/L at initial treatment is an independent prognostic factor for AML M5 patients(P<0.05).Conclusion Most AML M5 patients seek treat-ment with fever,and there are many factors that affect their prognosis,such as age≥60 years old,minimal residual lesions,PS score≥2 points,and white blood cell count>50 at initial treatment×109/L,etc.Therefore,clinical attention should be paid to the high-risk groups mentioned above and personalized prevention and treatment measures should be implemented.
万方数据
维普
