Effect of Postoperative Adjuvant Chemotherapy on Prognosis of Early Non-small Cell Lung Cancer Patients
Objective To investigate the effect of postoperative adjuvant chemotherapy on the prognosis of patients with early non-small cell lung cancer(NSCLC).Methods Clinical data of 100 early-stage NSCLC patients were reviewed.All patients were followed up for 3 years after surgery,and were divided into survival and death groups according to the survival.The basic da-ta of the 2 groups were collected for univariate analysis.Logistic regression analysis was performed after statistical differences were obtained to study independent risk factors affecting the prognosis of early NSCLC patients.According to whether underwent the postoperative adjuvant chemotherapy,the patients was divided into chemotherapy group and non chemotherapy group,and the difference between the clinicopathological characteristics,the median survival time and the survival rate of the 2 groups were com-pared.Results After 3 years of follow-up,85 early NSCLC patients survived,the survival rate was 85.00%(85/100);Degree of tumor differentiation,postoperative adjuvant chemotherapy,pleural infiltration,and postoperative risk factor scores between the death group and survival group had statistical difference(P<0.05);Multi-factor analysis revealed that,low differentiation,pleural infiltration,postoperative adjuvant chemotherapy and postoperative risk factor score≥2 were independent risk factors affecting the prognosis of early NSCLC patients(OR>1,P<0.05);Clinicopathological features between the adjuvant chemotherapy group and non adjuvant chemotherapy group had no significant difference(P>0.05);The median survival time of the adjuvant chemothera-py group[(30.14±3.58)months]was longer than that of the non adjuvant chemotherapy group[(26.39±2.79)months],there had statistical difference(t =5.856,P =0.000);3-year survival rate of the adjuvant chemotherapy group was 91.84%(45/49),and that of the non adjuvant chemotherapy group was 78.43%(40/51),There was no significant difference(χ2 =3.522,P =0.061).Conclusion Postoperative adjuvant chemotherapy is an independent risk factor affecting the prognosis of early NSCLC patients,and early postoperative adjuvant chemotherapy helps to prolong the survival time of NSCLC patients.
万方数据
维普
