Predictive Value of Serum CCL-20,PDGF-BB and CYFRA21-1 for Curative Effect of Targeted Therapy in NSCLC Patients
Objective To analyze the predictive value of serum chemokine ligand 20(CCL-20),platelet-derived growth factor BB(PDGF-BB)and cytokeratin fragment 19(CYFRA21-1)for curative effect of targeted therapy in patients with non-small cell lung cancer(NSCLC).Methods A total of 79 patients with advanced NSCLC underwent targeted therapy were enrolled.All were continuously treated for 2 months to evaluate the short-term curative effect.The general clinical data of patients were collect-ed.Before and after treatment,levels of serum CCL-20,PDGF-BB and CYFRA21-1 were detected.The differences of relevant data in patients with different curative effect were compared.The influencing factors of curative effect were analyzed.The predictive value of serum CCL-20,PDGF-BB and CYFRA21-1 for short-term curative effect was analyzed by ROC curves.Results The 2-month targeted therapy was completed in all the 79 patients with advanced NSCLC,and the total response rate of treatment was 45.57%(CR +PR,36/79).There were 36 cases in effective group and 43 cases in ineffective group(SD + PD).There was no significant difference in age,gender or pathological types between the 2 groups(P>0.05).The proportions of TNM staging at stage ⅢB and high differentiation in effective group were higher than those in ineffective group(P<0.05).Before and after treat-ment,levels of CCL-20,PDGF-BB and CYFRA21-1 in effective group were lower than those in ineffective group(P<0.05).The results of multivariate Logistic regression analysis showed that serum CCL-20,PDGF-BB and CYFRA21-1 were independent influ-encing factors of curative effect(OR =9.574,10.903,11.156,P<0.05).The results of ROC curves analysis showed that CCL-20,PDGF-BB and CYFRA21-1 were all of predictive value for clinical curative effect(AUC =0.775,0.896,0.669,P<0.05).Conclusion The levels of serum CCL-20,PDGF-BB and CYFRA21-1 are related curative effect of targeted therapy in patients with advanced NSCLC,which can be applied as auxiliary indexes to evaluate the short-term curative effect of targeted therapy.
万方数据
维普
