Relationship Between the Level of PD-1 on the Surface of CD+T Cells and Treg Cells and the Prognosis of Lung Cancer Patients After Operation
Objective To investigate the relationship between the level of programmed death receptor-1(PD-1)on the surface of CD+T cells and regulatory T(Treg)cells and the prognosis of lung cancer patients after operation.Methods 126 pa-tients with lung cancer who underwent radical resection were selected.The incidence of poor prognosis within 2 years after opera-tion was counted and divided into good group and bad group according to the prognosis.Univariate analysis of the factors influen-cing the poor prognosis of lung cancer patients after surgery.Logistic regression analysis was used to analyze the influencing fac-tors of poor prognosis of lung cancer patients after operation.The predictive value of the level of CD+T cells and Treg PD-1 on the prognosis of lung cancer patients after surgery was analyzed by the receiver operating characteristic curve(ROC).Results There were significant differences in tumor lymph node metastasis(TNM)stage,CD3+,CD3+CD4+,CD3+CD8+and Treg PD-1 levels between the two groups(P<0.05).Logistic regression analysis showed that low expression of CD3+ and CD3+ CD4+,high ex-pression of CD3+CD8+and high expression of Treg PD-1 were independent risk factors for poor prognosis of lung cancer patients after surgery(P<0.05).ROC analysis showed that the best cutoff points of CD3+,CD3+ CD4+,CD3+ CD8+ and Treg PD-1 for predicting the prognosis of lung cancer patients were 53.52%,27.94%,27.96%and 21.36%.And the area under the curve(AUC)was 0.731,0.810,0.691 and 0.969.Conclusion The low expression of CD3+and CD3+CD4+,the high expression of CD3+CD8+and the high expression of Treg PD-1 in lung cancer patients are associated with poor short-term prognosis.
Lung cancerRegulatory T cellsProgrammed death receptor-1Prognosis
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