Hypo-fractionated Adaptive Radiotherapy for Large Brain Metastasis:Dosimetric and Clinical Analysis
Objective To investigate the dosimetric and clinical analysis of hypo-fractionated adaptive radiotherapy in patients with large brain metastases.Methods A total of 20 patients with large brain metastases who were initially treated with hypo-fractionated adaptive radiotherapy and with lesion volume of 6 cm3 to 20 cm3 and the number of lesions 1 to 4 of radiothera-py were collected.The lesion was prescribed a dose of 52.5Gy/3.5Gy/15f,Patients were re-examined by MRI after 10 times treatment.The radiation field would be shrunk if the GTV was reduced,and complete the remaining dose of radiotherapy.Changes in dosimetric parameters of two segment planning brain and other organs at risk,rate of second segment planning tumor reduction,and recent efficacy were evaluated.Results The dosimetric parameters of brain tissue and organs at risk in plan2 were reduced to varying degrees.The average rate of tumor reduction during second segment field reduction was 41.76%,the 3-month ORR was 92.6%,and the 3-month,6-month LCR was 100%.Conclusion Hypo-fractionated adaptive radiotherapy has a high rate of tumor reduction,can effectively reduce the value of dosimetric parameters of normal brain tissue,and has a good local control rate for large-volume lesions,and best short-term results.
Large brain metastasesHypo-fractionated radiotherapyAdaptive radiotherapy
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维普
