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复发性脑胶质瘤患者再手术治疗的预后因素分析

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目的 探讨复发性脑胶质瘤患者再手术治疗的预后因素.方法 回顾性分析 80 例行再手术治疗的复发性脑胶质瘤患者临床资料,并对患者进行1 年左右的随访,记录其生存情况.结果 80 例脑胶质瘤患者再手术后1 年生存率为71.25%(57/80),中位生存时间为15 个月.与死亡组比较,存活组再手术前KPS评分、病理Ⅰ~Ⅱ级和全切手术者占比均较高(P<0.05),经Cox回归分析发现再手术前KPS评分、病理分级和手术切除范围是复发性脑胶质瘤患者再手术预后的影响因素(P<0.05).ROC曲线发现,再手术前KPS评分、病理分级和手术切除范围对预测患者再手术预后均具有一定价值,3 项联合时预测效能最高.结论 复发性脑胶质瘤患者再手术治疗后的 1 年生存率受再手术切除范围、术前KPS评分和病理分级的影响,可将其作为预测患者再手术后预后的因子.
Prognostic Factors of Reoperation in Patients with Recurrent Gliomas
Objective To explore the prognostic factors of reoperation in patients with recurrent gliomas.Methods The clinical data of 80 patients with recurrent glioma who underwent reoperation were analyzed retrospectively,and the patients were followed up for about 1 year to record their survival.Results The 1-year survival rate of 80 patients with glioma after reoperation was 71.25%(57/80),and the median survival time was 15 months.Compared with the death group,the survival group had higher KPS score,pathological grade Ⅰ~Ⅱ and total resection before reoperation(P<0.05).Cox regression analysis showed that KPS score before reoperation,pathological grade and surgical resection range were the influencing factors for the prognosis of patients with recurrent glioma after reoperation(P<0.05).The ROC curve showed that the KPS score before reoperation,pathological grade and surgical resection range had certain value in predicting the prognosis of patients,and the prediction efficiency of the three combined diagnoses was the highest.Conclusion The 1-year survival rate of patients with recurrent gliomas after reopera-tion is affected by the scope of reoperation,KPS score before reoperation and pathological grade,which can be used as a factor to predict the prognosis of patients after reoperation.

RecurrenceGliomaReoperationPrognosisSurvival ratePredictorsInfluence factor

田月玲、张辉、张文进、魏旭洋

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450000 郑州大学附属郑州中心医院

复发 脑胶质瘤 再手术 预后 生存率 预测因子 影响因素

河南省医学科技攻关计划联合共建项目(2019)

LHGJ20191045

2024

实用癌症杂志
江西省肿瘤医院 江西省肿瘤研究所

实用癌症杂志

影响因子:1.241
ISSN:1001-5930
年,卷(期):2024.39(4)
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