Correlation Analysis Between Cerebrospinal Fluid Levels of VEGF,HGF,and PDGF and Postoperative Recurrence in Patients with Glioma
Objective To investigate the cerebrospinal fluid expression of vascular endothelial growth factor(VEGF),hepatocyte growth factor(HGF),and platelet-derived growth factor receptor(PDGF)in patients with glioma and their correlations with postoperative recurrence.Methods A total of 70 patients with glioma were selected as the study subjects.The levels of VEGF,HGF,and PDGF in cerebrospinal fluid were analyzed by enzyme-linked immuno sorbent assay(ELISA).The recurrence of patients was followed-up 6 months after surgery,and the patients were divided into a recurrence group and a non-recurrence group.The correlation between the levels of 3 cytokines in cerebrospinal fluid and recurrence was analyzed.Results The levels of VEGF,HGF,and PDGF in cerebrospinal fluid of low-grade glioma patients were(22.13±2.87)pg/ml,(515.30±209.10)pg/ml,and(79.23±6.79)pg/ml.The levels of VEGF(30.22±2.82 pg/ml),HGF(1194.00±354.50 pg/ml),and PDGF(97.89±7.40 pg/ml)in cerebrospinal fluid of patients with high-grade glioma were significantly higher than those of patients with low-grade glioma(P<0.001).There was a significant positive correlation between VEGF,HGF,and PDGF levels in cerebro-spinal fluid of glioma patients(P<0.001).Binary logistic regression analysis showed that VEGF and HGF levels in the cerebro-spinal fluid of glioma patients were independent influencing factors for postoperative recurrence(P<0.05).Receiver operating characteristics(ROC)curve showed that the combination of VEGF and HGF had a certain predictive effect on postoperative recur-rence of glioma patients(AUC:0.856;P<0.001).Conclusion The levels of VEGF,HGF,and PDGF in the cerebrospinal fluid of glioma patients are significantly higher.The levels of VEGF and HGF in the cerebrospinal fluid are independent influencing fac-tors for postoperative recurrence,and the combination of VEGF and HGF have a certain predictive value for postoperative recur-rence.
万方数据
维普
