Objective To investigate the cerebrospinal fluid expression of vascular endothelial growth factor(VEGF),hepatocyte growth factor(HGF),and platelet-derived growth factor receptor(PDGF)in patients with glioma and their correlations with postoperative recurrence.Methods A total of 70 patients with glioma were selected as the study subjects.The levels of VEGF,HGF,and PDGF in cerebrospinal fluid were analyzed by enzyme-linked immuno sorbent assay(ELISA).The recurrence of patients was followed-up 6 months after surgery,and the patients were divided into a recurrence group and a non-recurrence group.The correlation between the levels of 3 cytokines in cerebrospinal fluid and recurrence was analyzed.Results The levels of VEGF,HGF,and PDGF in cerebrospinal fluid of low-grade glioma patients were(22.13±2.87)pg/ml,(515.30±209.10)pg/ml,and(79.23±6.79)pg/ml.The levels of VEGF(30.22±2.82 pg/ml),HGF(1194.00±354.50 pg/ml),and PDGF(97.89±7.40 pg/ml)in cerebrospinal fluid of patients with high-grade glioma were significantly higher than those of patients with low-grade glioma(P<0.001).There was a significant positive correlation between VEGF,HGF,and PDGF levels in cerebro-spinal fluid of glioma patients(P<0.001).Binary logistic regression analysis showed that VEGF and HGF levels in the cerebro-spinal fluid of glioma patients were independent influencing factors for postoperative recurrence(P<0.05).Receiver operating characteristics(ROC)curve showed that the combination of VEGF and HGF had a certain predictive effect on postoperative recur-rence of glioma patients(AUC:0.856;P<0.001).Conclusion The levels of VEGF,HGF,and PDGF in the cerebrospinal fluid of glioma patients are significantly higher.The levels of VEGF and HGF in the cerebrospinal fluid are independent influencing fac-tors for postoperative recurrence,and the combination of VEGF and HGF have a certain predictive value for postoperative recur-rence.
维普
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