Clinical Value of Tumor Stromal Ratio in the Prognostic Evaluation of Patients After Gastric Cancer
Objective To explore the clinical value of tumor interma ratio(TSR)in the prognosis evaluation of patients after gastric cancer.Methods 80 gastric cancer patients were selected as the study subjects,and all the patients underwent radi-cal gastrectomy and D2 lymph node dissection.TSR was performed,taking those with low TSR as the final value,high TSR excee-ded50%,and not low interstitial group.Long-term follow-up.The overall survival and disease-free survival of all patients were counted,and the risk factors affecting overall survival and disease-free survival were analyzed by COX regression.Results In 80 patients with gastric cancer,37 patients had high interstitial ratio,Low interstitial ratio in 43 cases;Compared with the 2 groups:T stage,N stage,TNM stage,lymphovascular invasion and perinerve invasion,The difference was statistically significant(P<0.05);Median follow-up time was 27 months(6-46)months,25 out of the 80 patients died(31.25%),55 patients survived(68.75%);The 3-year overall survival rate of the 80 patients was 73.75%(59/80);After the R0 resection,41 relapsed(51.25%),The 3-year disease-free survival rate was 42.50%(34/80);The 3-year overall survival rate in the high interstitial ratio group was 89.19%(33/37),Higher than 60.47%(26/43),The 3-year disease-free survival rate was 56.76%(21/37),Higher than 30.23%(13/43)of the low interstitial ratio group,The difference was significantly significant(χ2 =8.476,5.725,P =0.004,0.016);The COX multivariate regression analysis showed that,TNM stage,perineural infiltration,and TSR were the independent risk factors affecting the overall survival and disease-free survival of GC patients after surgery(P<0.05).Conclusion TSR has a high value in evaluating patient prognosis after gastric cancer.Low tumor stroma has a higher risk of poor prognosis than pa-tients,and can be included in routine pathological examination.
万方数据
维普
