Study on the Application of Hepatic Artery Interventional Chemoembolization in Postoperative Patients with Primary Liver Cancer
Objective To explore the therapeutic effect of hepatic artery interventional chemotherapy embolization on postoperative patients with primary liver cancer.Methods 100 patients with primary liver cancer were selected as the observation subjects and divided into 2 groups using a random number table method,with 50 patients in each group.Laparoscopic guided tumor resection was performed in both groups.At the same time,the study group was treated with hepatic artery interventional chemotherapy and embolization 7 days after surgery.The follow-up was 2 years.The levels of liver function indicators[AST,TBIL and ALT],serum tumor markers[carbohydrate antigen 19-9(CA19-9),alpha fetoprotein(AFP)and phosphatidylinositol proteo-glycan-3(GPC3)],and quality of life[QOL-LC]were compared between the 2 groups before and after treatment,and the postop-erative recurrence rate and survival rate were calculated.Results Compared with that before treatment,the levels of AST,TBIL and ALT in serum of the 2 groups increased 7 days after treatment,and the levels of AST,TBIL and ALT in the study group were higher than those in the control group,with a statistically significant difference(P<0.05);Compared with that before treatment,the levels of serum CA19-9,AFP and GPC3 in the two groups decreased one month after treatment,and the levels in the study group were lower than those in the control group,with a statistically significant difference(P<0.05);Compared with that before treatment,the QOL-LC scores of patients in the two groups increased one month after treatment,and the score of the study group(185.74±12.34)was higher than that of the control group(164.30±11.55),with a statistically significant difference(P<0.05);2 year recurrence rate after treatment in the study group was 26.00%(13/50),which was lower than 50.00%(25/50)in the control group,and the survival rate was 84.00%(42/50),which was higher than 64.00%(32/50)in the control group.The difference was statistically significant(P<0.05).Conclusion Hepatic artery interventional chemoembolization assisted with tumor resection is more effective in the treatment of primary liver cancer,which can effectively reduce the expression level of ser-um tumor markers,improve lung function and quality of life,improve the clinical survival rate,and benefit the prognosis.
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