Correlation Analysis of miR-647,miR-122,KMT2D Expression with Clinical Pathological Characteristics and Prognosis of Prostate Cancer
Objective To investigate the correlation between minimal RNA-647(miR-647),minimal RNA-122(miR-122),histone lysine methyltransferase 2D(KMT2D),clinical pathological features,and prognosis in prostate cancer tissue.Meth-ods 100 patients with prostate cancer were selected as the research subjects,and tumor tissue and adjacent normal tissue sam-ples were collected during surgery for examination.The expression levels of miR-647,miR-122,and KMT2D in tumor tissue and adjacent normal tissue were statistically analyzed;Analyzed the relationship between miR-647,miR-122,KMT2D expression and tumor staging,tumor diameter,lymph node metastasis,microvascular invasion,etc;And followed up for 2 years to compare the differences in miR-647,miR-122,and KMT2D expression between patients with recurrence and metastasis and those without re-currence and metastasis.Results The expression level of miR-647 in tumor tissue was(0.62±0.13),lower than that in normal tissues adjacent to cancer(1.02±0.19).The expression levels of miR-122 and KMT2D were(6.45±1.24)and(1.45±0.23),lower than those in the control group(1.23±0.22)and(0.89±0.12)(P<0.05);The expression levels of miR-647 in patients with tumor stage Ⅲ,tumor diameter≥3cm,lymph node metastasis,and microvascular invasion were lower than those in patients with tumor stage Ⅰ-Ⅱ,tumor diameter<3cm,no lymph node metastasis,and no microvascular invasion.The expression levels of miR-122 and KMT2D were higher than those in patients with tumor stage Ⅰ-Ⅱ,tumor diameter<3 cm,no lymph node metastasis,and no microvascular invasion(P<0.05);100 patients were followed up for 2 years after surgery,with a total of 24 cases experi-encing recurrence and metastasis,with a recurrence and metastasis rate of 24.00%(24/100);The expression level of miR-647 in patients with recurrence and metastasis was(0.51±0.11),lower than that in patients without recurrence and metastasis(0.73±0.15).The expression levels of miR-122 and KMT2D were(8.42±1.39)and(1.89±0.32),higher than those in patients with-out recurrence and metastasis(4.68±1.02)and(1.12±0.15)(P<0.05).Conclusion miR-647,miR-122,and KMT2D are expressed to varying degrees in prostate cancer tissue,which are closely related to tumor staging,tumor diameter,and lymph node metastasis,and can significantly affect patient prognosis.Clinical attention should be paid to these factors.
Prostate cancerMicro RNA-647Micro RNA-122Histone lysine methyltransferase 2DClinical pathological features
万方数据
维普
