Clinical Significance of Second Transurethral Holmium Laser Resection of Non Muscle Invasive Bladder Cancer
Objective To investigate the clinical effect of second transurethral holmium laser resection of non muscle in-vasive bladder cancer(NMIBC).Methods 82 patients with NMIBC were selected and divided into 2 groups according to the random number table,41 patients in each group.The control group was treated with transurethral resection of bladder tumor(TURBT),and the observation group was treated with transurethral resection of bladder tumor with holmium laser.The surgical condition,inflammatory factor level,oxidative stress factor,accuracy of pathological diagnosis and complications were compared between the 2 groups.Results The time of gross hematuria[(1.29±0.23)d],indwelling catheter[(2.35±0.27)d],and postoperative bladder flushing[(1.42±0.25)d]in the observation group were shorter than those in the control group,with sta-tistical differences(P<0.05);Interleukin-6(IL-6)[(67.25±6.19)pg/mL],C-reactive protein(CRP)[(17.25±2.19)mg/L]and tumor necrosis factor in the observation group after treatment-α(TNF-α)[(40.39±4.28)pg/ml]level was lower than that of the control group(P<0.05);After treatment,the level of malondialdehyde(MDA)[(5.74±1.05)mmol/L]in the obser-vation group was lower than that in the control group,and the level of superoxide dismutase(SOD)[(105.96±9.58)μ The levels ofmol/L]andglutathione peroxidase(GSH Px)[(70.14±6.23)pg/ml]were higher than those in the control group(P<0.05);The accuracy rate of pathological diagnosis[90.24%(37/41)]in the observation group was higher than that in the con-trol group,and the complication rate[4.88%(2/41)]was lower than that in the control group,with statistical difference(P<0.05).Conclusion The second transurethral resection of bladder tumor with holmium laser is more effective in the treatment of NMIBC,which can reduce the surgical trauma,shorten the time of gross hematuria and catheter retention,reduce the inflammatory reaction and oxidative stress reaction,and the resected specimen is more consistent with the pathological staging requirements,safe and reliable.
Bladder cancerSecondary transurethral resection of bladder tumorHolmium laserRecurrence rateCom-plication
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