Expressions and Clinical Predictive Value of MMP-9 and IGF-1 in Patients with Pituitary Adenoma
Objective To explore the expressions and clinical predictive value of MMP-9 and IGF-1 in patients with pi-tuitary adenoma.Methods Clinical data of 84 patients with pituitary adenoma were retrospectively analyzed.The differences in serum indicators[matrix metalloproteinase9(MMP-9),insulin-like growth factor 1(IGF-1)]were analyzed among patients with different pathological pituitary adenomas.According to the tumor diameter size and metastasis rate of 84 patients with pituitary ad-enoma after treatment,they were divided into remission group(n=40)and non-remission group(n=44).Receiver operating characteristic(ROC)curve was used to analyze the evaluated efficiency of MMP-9 and IGF-1 on the prognosis of patients with pi-tuitary adenoma.Results There were no significant differences in the levels of MMP-9 and IGF-1 in pituitary adenoma patients with different tumor diameters(P＞0.05).The level of MMP-9 in patients without lymph node metastasis was significantly lower than that in patients with metastasis while the level of IGF-1 was higher than that in patients with metastasis(P＜0.05).The level of MMP-9 in patients with pituitary adenoma of clinical stage Ⅰ to Ⅱ was significantly lower than that in patients with stage Ⅲ toⅣ while the level of IGF-1 was higher than that in patients with stage Ⅲ to Ⅳ(P＜0.05).MMP-9 in remission group was lower than that in non-remission group while IGF-1 level was significantly higher than that in non-remission group(P＜0.05).ROC curve results showed that the cutoff values of serum MMP-9 and IGF-1 were 16.61ng/L and 229.06ng/L respectively.The area under ROC curve(AUC),sensitivity and specificity of MMP-9 were 0.871(95％CI=0.778～0.935),75.61％and 92.50％.The AUC of ROC curve,sensitivity and specificity of IGF-1 were 0.851(95％CI=0.755～0.921),75.61％and 87.50％re-spectively.Conclusion Serum levels of MMP-9 and IGF-1 are closely related to the clinicopathological features and prognosis of patients with pituitary adenoma,and early detection results can further optimize the diagnosis and treatment measures.
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