Expression and Clinical Significance of OPN,Pyk2,ERK,and MMP-9 in Cancer Tissues of Tongue Cancer Patients
Objective To analyze the expression and clinical significance of osteopontin(OPN),proline rich tyrosine ki-nase 2(Pyk2),extracellular signal-regulated kinase(ERK),and matrix metalloproteinase-9(MMP-9)in tongue cancer tissue.Methods 62 patients with tongue cancer were selected,and their cancer tissue and adjacent normal tissue(≥ 3 cm from the edge of the lesion)were collected.They were included in the observation group and the control group respectively,and the differences in OPN,Pyk2,ERK,and MMP-9 between the 2 groups were compared.Collect age,gender and other data of patients,and analyze the relation between OPN,Pyk2,ERK,MMP-9 and various clinical pathological characteristics of patients.Results The positive expression rates of OPN,Pyk2,ERK,and MMP-9 in the observation group were higher than those in the control group,and the difference was statistically significant(P＜0.05).The expression of OPN,Pyk2,ERK,and MMP-9 was not related to age,gender,and tumor diameter of tongue cancer patients(P＞0.05),but was related to clinical stage,degree of differentiation,and lymph node metastasis(P＜0.05).Conclusion OPN,Pyk2,ERK,and MMP-9 are abnormally high expressed in the cancer tissue of tongue cancer patients,and are closely related to the clinical stage,degree of differentiation,and lymph node metastasis of the pa-tients.
万方数据
维普
